To assess associations between serum TGF-β1 and radiographic knee and hip osteoarthritis (rOA) in African American (AA) and White men and women

Fang, F.

Helmick, C. G.

Jordan, J. M.

Kraus, V. B.

Nelson, A. E.

Renner, J. B.

Schwartz, T. A.

Shi, X. A.

Stabler, T.

PubMed

SummaryPurposeTo assess associations between serum transforming growth factor-beta (TGF-β1) and radiographic knee and hip osteoarthritis (rOA) in African American (AA) and White men and women.MethodsBaseline data from 330 participants in the Johnston County Osteoarthritis Project were used in the analysis. Radiographs were scored with the Kellgren–Lawrence scale and rOA defined as grade≥2. Individual radiographic features (IRFs) were rated 0–3. TGF-β1 was measured using a sandwich enzyme-linked immunosorbent assay (ELISA). General linear models were used to estimate associations between lnTGF-β1 and rOA presence, laterality or severity, and IRF presence and severity, adjusting for age, gender, race and body mass index. Interactions by race and gender were considered significant at P<0.1.ResultsMean lnTGF-β1 levels were higher among AAs compared to Whites, and among women compared to men (P<0.009). Mean lnTGF-β1 levels were higher in those with knee osteophytes (OST), but this association was not significant after adjustment. There were no other significant differences in mean lnTGF-β1 levels by presence, laterality, or severity of knee or hip rOA or IRFs. No race or gender interactions were identified, although a borderline significant association between lnTGF-β1 and knee OST was seen among AAs (P<0.06).ConclusionsAlthough serum TGF-β1 varied by race and gender and several rOA variables, there were no independent significant associations with presence, laterality, or severity of knee or hip rOA by K–L grade or IRFs, suggesting that serum TGF-β1 is unlikely to be useful as a stand-alone biomarker in OA studies. A possible association between TGF-β1 and OST in AAs cannot be excluded

Nelson, A.E.

Shi, X.A.

Kraus, V.B.

Renner, J.B.

Schwartz, T.A.

Helmick, C.G.

Jordan, J.M.

Elsevier - Publisher Connector 

Failure of serum transforming growth factor-beta (TGF-β1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project 

Carolina Digital Repository

Failure of serum transforming growth factor-beta (TGF-β1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project

https://cdr.lib.unc.edu/downloads/jw827k79b

Failure of serum transforming growth factor-beta (TGF-β1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project

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Elsevier - Publisher Connector

Carolina Digital Repository

Elsevier - Publisher Connector