Hisatome, Ichiro

Kuwabara, Masanari

Niwa, Koichiro

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HYPERURICEMIA IS AN INDEPENDENT RISK FACTOR OF ATRIAL FIBRILLATION 

A469
JACC April 1, 2014
Volume 63, Issue 12
Arrhythmias and Clinical EP
hypEruricEmia is an indEpEndEnt risk factor of atriaL fibriLLation
Poster Contributions
Hall C
Monday, March 31, 2014, 9:45 a.m.-10:30 a.m.
Session Title: Arrhythmias and Clinical EP: New Observations on Pathophysiology of Atrial Fibrillation
Abstract Category: 4. Arrhythmias and Clinical EP: AF/SVT
Presentation Number: 1256-121
Authors: Masanari Kuwabara, Koichiro Niwa, Ichiro Hisatome, Department of Cardiology, Toranomon Hospital, Tokyo, Japan, Regenerative 
Medicine and Therapeutics, Graduate School of Medical Science,Tottori University, Yonago, Japan
background: Uric acid transporter is proposed to play a pivotal role of hyperuricemia-induced cardiovascular-renal disease. We reported that 
hyperuricemia impaired the ion channel expression of atrial myocytes to induce electrical remodeling, contributing to atrial fibrillation (AF). Though, 
the relationship between uric acid and AF was not clear yet. This study was conducted to clarify the relationship between uric acid and AF by using 
general population mass data.
methods: We analyzed the medical records of 90,143 Japanese people (male:49.1%, age:46.3±12.0 years) who had annual medical check-up 
in St. Luke’s international hospital, Tokyo, Japan from January, 2004 to June, 2010. AF was diagnosed by 12 leads-electrocardiography. Only 291 
patients (0.32%) were depicted as AF in ECG. We excluded hypertension, diabetes, dyslipidemia, and chronic kidney disease (CKD) cases because 
these might be risk factors of AF. We detected independent risk factors for AF and obtained odds ratio (OR) by logistic regression analysis.
results: We excluded 40,568 cases; insufficient data 18 (0.02%), hypertension 13,967 (15.5%), diabetes 3,776 (4.2%), dyslipidemia 32,052 
(35.6%), and CKD 5,147 (5.7%). We analyzed 49,575 general healthy people. Risk factors of AF were aging (OR per 1 year increased: 1.12, 
p<0.001), male (OR: 4.40, p=0.002), higher BMI (OR per 1 kg/m2: 1.13, p=0.008), higher serum uric acid (OR per 1 mg/dL increased :1.52, 
p<0.001) significantly. Smoking (OR: 1.64, p=0.089) was not significant. Hyperuricemia (serum uric acid ≥7.0 mg/dL) was significantly independent 
risk factor of AF (OR:2.41, p<0.001).
conclusions: Hyperuricemia is one of the strong independent risk factor of AF in general population. The intervention for hyperuricemia might be 
prevention of AF provocation.


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HYPERURICEMIA IS AN INDEPENDENT RISK FACTOR OF ATRIAL FIBRILLATION

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