Background:Apolipoprotein M (ApoM) is bound to high-density lipoprotein (HDL) in plasma, and HDL has
anticoagulation effects. However, the association between ApoM and biomarkers of coagulation was unclear.
Therefore, we investigated relationships between ApoM and biomarkers of coagulation.
Methods: Serum samples from 233 Japanese participants including with diabetes mellitus, hypertension,
dyslipidemia, or healthy controls were analyzed. Serum ApoM levels were measured using Enzyme-Linked
Immuno-Sorbent Assay(ELISA).
Results:Analysis of all 233 participants showed that ApoM levels were positively correlated with age (r=0.284,
p<0.001), total cholesterol (TC;r=0.477, p<0.001), HDL-cholesterol (HDL-C;r=0.234, p<0.001) and lowdensity
lipoprotein cholesterol (LDL-C;r=0.331, p<0.001). Higher ApoM levels were correlated with shorter
activated partial thromboplastin time(APTT;r=-0.226,p=0.001) and prothrombin time(PT,%;r=0.326,p<
0.001). Separate analysis of the 115 healthy controls showed that ApoM levels were positively correlated with age,
TC, HDL-C and LDL-C, and higher ApoM levels were correlated with shorter PT.
Conclusion:Serum levels of ApoM may influence biomarkers of coagulation