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Experimental and theoretical studies of the interaction of Penicillamine with SWCNT (6,0) as a drug delivery system
Authors
F. Ashrafi
A.S. Ghasemi
+4 more
B. Makiabadi
F. Mashhadban
A. Soltani
M. Zakarianezhad
Publication date
1 January 2022
Publisher
Abstract
In this paper the interaction of Penicillamine (PCA) with single-walled carbon nanotube (SWCNT)(6,0) has been studied experimentally and theoretically. The element mapping (MAP) analysis has been indicated that the drug was adsorbed and distributed throughout the SWCNT (6,0) surface. The obtained FTIR spectrum confirms the presence of PCA on the surface of nanotube. The images of Field Emission Scanning Electron Microscope (FE-SEM) clearly demonstrate that the compound is fused in irregular films of nanometer size in which composed of very small spherical particles. The results of Energy Dispersive X-ray Analysis (EDAX) also, have been confirmed the combination of PCA with nanotube. TEM images have been clearly indicated the possibility of physical interaction between the CNT and the functional group of drug. These results have confirmed that the interaction of PCA with nanotube can be considered as a physical adsorption. The results obtained by the computational have confirmed the experimental data. © 2022 Taylor & Francis Group, LLC
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Last time updated on 19/05/2022