Contamination and Prevalence of Histamine in Canned Tuna from Iran: A Systematic Review, Meta-Analysis, and Health Risk Assessment

Abstract

HIGHLIGHTS: Data from 11 articles and a total of 693 samples were used for a meta-analysis. Pooled mean histamine, 77.86 mg kg-1, was lower than the FDA limit (200 mg kg-1). Pooled mean histamine prevalence was 9.19 with considerable heterogeneity. THQ value <1 indicates that adult consumers are not at risk of histamine poisoning