CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
The impaired balance of CD4+/CD8+ ratio in patients with chronic hepatitis B
Authors
S. Ahmady-Asbchin
T. Amiriani
+7 more
S. Besharat
B. Khodabakhshi
S. Mohammadi
A. Norouzi
F. Roudbari
I. Shahabinasab
N. Shokoohifar
Publication date
1 January 2020
Publisher
Abstract
Background: The role of immune system in natural course of viral hepatitis has been drawn some attention. One of the main diagnostic markers of the immune system function in different diseases might be the ratio of CD4+ to CD8+ T lymphocytes (CD4+/CD8+ ratio). Objectives: This research aimed to measure and compare CD4+/CD8+ ratio in the patients with chronic hepatitis B (CHB) and control group. Methods: In this cross-sectional study, thirty-three CHB patients and thirty age and sex-matched healthy controls were included. Immunophenotyping of isolated T cells was performed using specific anti-CD4 and anti-CD8 antibodies by flow cytometry. Conse-quently, CD4+, CD8+ and the ratio of CD4+/CD8+were counted and compared between the two groups. Results: CD4+ counts () were considerably reduced in patients with CHB compared to the healthy controls (51.22 ± 10.5 vs. 63.14 ± 9.9, P = 0.00), whereas CD8+ counts () were higher in the patients with CHB than healthy controls (48.8 ± 10.5 vs. 36.85 ± 9.86, P = 0.00). Moreover, CD4+/CD8+ ratio remarkably decreased in the patients with CHB (1.15 ± 0.5) than healthy controls (1.93 ± 0.9) (P = 0.00). Area under curve (AUC) of 0.79 (SE = 0.06, CI = 0.68-0.90, P value = 0.05) was reported for CD4+/CD8+ ratio with a sensitivity of 72.73 and specificity of 73.33 in 1.35 cut-off (likelihood ratio = 2.72). Conclusions: The research indicated an impaired balance between T cell subsets associated with a higher proportion of CD8+ T cells and a lower proportion of CD4+ T cells and CD4+/CD8+ ratio in patients with CHB. © 2020, Author(s)
Similar works
Full text
Available Versions
Golestan University of Medical Sciences Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.goums.ac.ir:10603
Last time updated on 14/05/2020