CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Long-term evaluation of a historical cohort of Iranian common variable immunodeficiency patients
Authors
H. Abolhassani
A. Aghamohammadi
+32 more
S. Aleyasin
R. Amin
S. Bazregari
N. Behniafard
M.H. Bemanian
T. Cheraghi
A. Dabbaghzade
M. Ebrahimi
M. Ebrahimi
M.H. Eslamian
R. Faridhosseini
J. Ghaffari
M. Gharagozlou
L. Hammarström
F. Jabbari-Azad
N. Kalantari
S. Kashef
A. Khalili
A. Khayatzadeh
A. Latif
B. Mirminachi
I. Mohammadzadeh
M. Movahedi
N. Parvaneh
D. Razavinejad
N. Rezaei
A. Shafiei
S. Shahinpour
R. Sherkat
T. Shokuhfar
F. Tabassomi
B. Torabi Sagvand
Publication date
1 January 2014
Publisher
Expert Reviews Ltd.
Doi
Cite
Abstract
Objectives: Common variable immune deficiency (CVID) is the most frequent form of symptomatic primary immunodeficiency disease, characterized by hypogammaglobulinemia, recurrent infections and increased predisposition to autoimmunity and malignancies. The aim of this study was to reconsider important points of previously performed studies on Iranian CVID patients diagnosed and followed from 1984 to 2013. Methods: Diagnosis was made using approved criteria including reductions of serum levels of immunoglobulins and exclusion of well-known single gene defects in individuals with an age >4 years and evidence of specific antibody deficiency. Results: Detailed information on demographic data, survival rates, clinical phenotypes, immunologic and genetic data and treatment of 173 patients are provided. The early onset presentation (74.5) and rate of consanguineous marriage (61.2) were considerably higher in our cohort. Our study revealed clinically related correlations regarding consanguinity, the population of naïve CD4+T cells and switched-memory B cells, cytokine levels and special genetic factors (including HLA and AID genes). Conclusion: Despite current efforts, more comprehensive studies are needed, especially for classification and investigation of the genetic background and prognostic factors for patients with CVID in order to better managment and followup of patinets. © 2014 Informa UK, Ltd
Similar works
Full text
Available Versions
Golestan University of Medical Sciences Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.goums.ac.ir:9273
Last time updated on 04/08/2017