International audienceMichel Daudon is a worldwide recognized biologist who performed several major breakthroughs in the field of urolithiasis. It is indeed difficult to address his outstanding personality and his great contributions to urolithiasis. Michel Daudon studied many aspects of urolithiasis, from urine crystals to kidney stone morphoconstitutional analysis. He is the author of more than 500 scientific articles on urolithiasis, and more generally on pathological calcifications, including several books and nice articles in the New England Journal of Medicine, The Lancet, Kidney International, among many others. Michel Daudon is not only a prolific writer; his broad fields of interests range from chemistry to biology or renal pathology, but also clinical bedside subjects explain his success and his attractive way of explaining pathophysiological processes. He has already given more than 300 lectures, in France as abroad

Dominique Bazin

Emmanuel Letavernier

Jean Philippe Haymann

Bazin, Dominique

Haymann, Jean Philippe

Letavernier, Emmanuel

Archive Ouverte en Sciences de l'Information et de la Communication

From urolithiasis to pathological calcifications: A journey at the interface between physics, chemistry, and medicine. A tribute to Michel Daudon

Comptes Rendus Chimie

C. R. Chimie 19 (2016) 1388lable at ScienceDirectContents lists avaiComptes Rendus Chimiewww.sciencedirect.comForeword/Avant-proposFrom urolithiasis to pathological calcifications: A journey at theinterface between physics, chemistry, and medicine. A tribute toMichel DaudonForewordMichel Daudon is aworldwide recognized biologist whoperformed several major breakthroughs in the field ofurolithiasis. It is indeed difficult to address his outstandingpersonality and his great contributions to urolithiasis.Michel Daudon studied many aspects of urolithiasis, fromurine crystals to kidney stone morphoconstitutional anal-ysis. He is the author of more than 500 scientific articles onurolithiasis, and more generally on pathological calcifica-tions, including several books and nice articles in the NewEngland Journal of Medicine, The Lancet, Kidney Interna-tional, among many others. Michel Daudon is not only aprolific writer; his broad fields of interests range fromchemistry to biology or renal pathology, but also clinicalbedside subjects explain his success and his attractive wayof explaining pathophysiological processes. He has alreadygiven more than 300 lectures, in France as abroad.Among his numerous findings, he developed 25 yearsago a novel characterization and classification of kidneystones according to morphology, combined with infraredanalysis, allowing one to diagnose a specific origin such asgenetics, diet disorders, infections, or drug-related stones.Michel Daudon is an exemplary biologist and an example toall younger generations, as he dedicated himself to theimprovement of knowledge and has been particularlyinvolved in the training of technicians, biologists, andphysicians. He has created a famous French Universitycourse dedicated to urolithiasis more than 15 years ago,and has been organizing a multidisciplinary urolithiasiscongress called “Confrontations clinico-biologiques sur lalithiase urinaire” for now 20 years.To illustrate the major findings relevant to clinical prac-tice, we can mention the identification of calcium oxalatekidney stoneswith Icmorphology, assessing the diagnosis ofprimary hyperoxaluria type I and calcium phosphate stoneswith IVa2 morphology, revealing distal tubular acidosis.Another strikingpoint andsignificantexample taken fromhis research is related to adenine phosphoribosyltransferasehttp://dx.doi.org/10.1016/j.crci.2016.10.0011631-0748/© 2016 Académie des sciences. Published by Elsevier Masson SAS.creativecommons.org/licenses/by-nc-nd/4.0/).deficiency. This pathology is a rare autosomal recessive dis-order characterized by 2,8-dihydroxyadenine crystalluria.Without treatment, the kidney function can decline and leadto end-stage renal disease. Although this pathology is almostcompletely ignored inother countries (less than10caseshavebeen reported in theUnited States and inGermany), between1978 and 2014 his laboratory identified this disease in 67patients from 56 families: 27 pediatric cases and 40 adultcases. Many of these diagnoses were performed through thedevelopment of new infrared microscopic analyses allowingone to characterize crystalline phases in kidney biopsies.In conclusion, for this under-recognized and treatablemonogenic disease aswell as for urolithiasis in general,MichelDaudon has been developing original morphoconstitutionalapproaches to characterize pathological calcifications.Appendix A. Supplementary dataThe comprehensive list of the publications by MichelDaudon can be found at http://dx.doi.org/10.1016/j.crci.2016.10.001.Dominique Bazin*Laboratoire de physique des solides, UMR 8502, bâtiment 510,91405 Orsay, FranceJean Philippe HaymannINSERM U 489, Universite Paris-6 and AssociationClaude-Bernard, Explorations fonctionnelles multidisciplinaires,Hôpital Tenon, 4, rue de la Chine, 75020 Paris, FranceE-mail address: jean-philippe.haymann@tnn.aphp.frEmmanuel LetavernierExplorations fonctionnelles multidisciplinaires, HôpitalTenon,4, rue de la Chine, 75020 Paris, FranceE-mail address: emmanuel.letavernier@tnn.aphp.fr Corresponding author.E-mail address: bazin@lps.u-psud.frAvailable online 28 October 2016This is an open access article under the CC BY-NC-ND license (http://

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From urolithiasis to pathological calcifications: A journey at the interface between physics, chemistry, and medicine. A tribute to Michel Daudon 

C. R. Chimie 19 (2016) 1388
lable at ScienceDirectContents lists avaiComptes Rendus Chimie
www.sciencedirect.comForeword/Avant-proposFrom urolithiasis to pathological calciﬁcations: A journey at the
interface between physics, chemistry, and medicine. A tribute to
Michel DaudonForeword
Michel Daudon is aworldwide recognized biologist who
performed several major breakthroughs in the ﬁeld of
urolithiasis. It is indeed difﬁcult to address his outstanding
personality and his great contributions to urolithiasis.
Michel Daudon studied many aspects of urolithiasis, from
urine crystals to kidney stone morphoconstitutional anal-
ysis. He is the author of more than 500 scientiﬁc articles on
urolithiasis, and more generally on pathological calciﬁca-
tions, including several books and nice articles in the New
England Journal of Medicine, The Lancet, Kidney Interna-
tional, among many others. Michel Daudon is not only a
proliﬁc writer; his broad ﬁelds of interests range from
chemistry to biology or renal pathology, but also clinical
bedside subjects explain his success and his attractive way
of explaining pathophysiological processes. He has already
given more than 300 lectures, in France as abroad.
Among his numerous ﬁndings, he developed 25 years
ago a novel characterization and classiﬁcation of kidney
stones according to morphology, combined with infrared
analysis, allowing one to diagnose a speciﬁc origin such as
genetics, diet disorders, infections, or drug-related stones.
Michel Daudon is an exemplary biologist and an example to
all younger generations, as he dedicated himself to the
improvement of knowledge and has been particularly
involved in the training of technicians, biologists, and
physicians. He has created a famous French University
course dedicated to urolithiasis more than 15 years ago,
and has been organizing a multidisciplinary urolithiasis
congress called “Confrontations clinico-biologiques sur la
lithiase urinaire” for now 20 years.
To illustrate the major ﬁndings relevant to clinical prac-
tice, we can mention the identiﬁcation of calcium oxalate
kidney stoneswith Icmorphology, assessing the diagnosis of
primary hyperoxaluria type I and calcium phosphate stones
with IVa2 morphology, revealing distal tubular acidosis.
Another strikingpoint andsigniﬁcantexample taken from
his research is related to adenine phosphoribosyltransferasehttp://dx.doi.org/10.1016/j.crci.2016.10.001
1631-0748/© 2016 Académie des sciences. Published by Elsevier Masson SAS.
creativecommons.org/licenses/by-nc-nd/4.0/).deﬁciency. This pathology is a rare autosomal recessive dis-
order characterized by 2,8-dihydroxyadenine crystalluria.
Without treatment, the kidney function can decline and lead
to end-stage renal disease. Although this pathology is almost
completely ignored inother countries (less than10caseshave
been reported in theUnited States and inGermany), between
1978 and 2014 his laboratory identiﬁed this disease in 67
patients from 56 families: 27 pediatric cases and 40 adult
cases. Many of these diagnoses were performed through the
development of new infrared microscopic analyses allowing
one to characterize crystalline phases in kidney biopsies.
In conclusion, for this under-recognized and treatable
monogenic disease aswell as for urolithiasis in general,Michel
Daudon has been developing original morphoconstitutional
approaches to characterize pathological calciﬁcations.
Appendix A. Supplementary data
The comprehensive list of the publications by Michel
Daudon can be found at http://dx.doi.org/10.1016/j.crci.
2016.10.001.
Dominique Bazin*
Laboratoire de physique des solides, UMR 8502, ba^timent 510,
91405 Orsay, France
Jean Philippe Haymann
INSERM U 489, Universite Paris-6 and Association
Claude-Bernard, Explorations fonctionnelles multidisciplinaires,
Ho^pital Tenon, 4, rue de la Chine, 75020 Paris, France
E-mail address: jean-philippe.haymann@tnn.aphp.fr
Emmanuel Letavernier
Explorations fonctionnelles multidisciplinaires, Ho^pitalTenon,
4, rue de la Chine, 75020 Paris, France
E-mail address: emmanuel.letavernier@tnn.aphp.fr
 Corresponding author.
E-mail address: bazin@lps.u-psud.fr
Available online 28 October 2016This is an open access article under the CC BY-NC-ND license (http://


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From urolithiasis to pathological calcifications: A journey at the interface between physics, chemistry, and medicine. A tribute to Michel Daudon

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