Inferring ADR causality by predicting the Naranjo Score from Clinical Notes

Abstract

Clinical judgment studies are an integral part of drug safety surveillance and pharmacovigilance frameworks. They help quantify the causal relationship between medication and its adverse drug reactions (ADRs). To conduct such studies, physicians need to review patients\u27 charts manually to answer Naranjo questionnaire(1). In this paper, we propose a methodology to automatically infer causal relations from patients\u27 discharge summaries by combining the capabilities of deep learning and statistical learning models. We use Bidirectional Encoder Representations from Transformers (BERT)(2) to extract relevant paragraphs for each Naranjo question and then use a statistical learning model such as logistic regression to predict the Naranjo score and the causal relation between the medication and an ADR. Our methodology achieves a macro-averaged f1-score of 0.50 and weighted f1-score of 0.63

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