Baillet, Sylvain

Schindler-Ivens, Sheila M.

Schmit, Brian

Swedler, Ruth M

English

epublications@Marquette

Marquette Universitye-Publications@MarquettePhysical Therapy Faculty Research and Publications Physical Therapy, Department of10-14-2012Neuromagnetic Activity in the Cerebral Cortex isModulated by Locomotor-Like MovementsProduced during PedalingSheila M. Schindler-IvensMarquette University, sheila.schindler-ivens@marquette.eduRuth M. SwedlerMarquette UniversityBrian SchmitMarquette University, brian.schmit@marquette.eduSylvain BailletMcGill UniversityAbstract. Sheila Schindler-Ivens, Ruth Swedler, Brian Schmit, and Sylvain Baillet. Presentation givenat the Neuroscience 2012 conference, 2012.OASISfile:///I|/Projects/IR/Faculty_Students/College_Health-Sciences/Schindler-Ivens/ViewAbstract.aspx.htm[1/3/2013 11:55:36 AM] Home > Presenter Index > Search Results > Presentation Detail Quick LinksPresentation AbstractProgram#/Poster#: 274.13/JJ11Presentation Title: Neuromagnetic activity in the cerebral cortex is modulated by locomotor-like movements produced duringpedalingLocation: Hall F-JPresentation time: Sunday, Oct 14, 2012, 1:00 PM - 2:00 PMAuthors: *S. M. SCHINDLER-IVENS1, R. SWEDLER2, B. SCHMIT3, S. BAILLET4,5; 1Physical Therapy, 2Physical Therapy and Biomed. Engin., 3Biomed. Engin., Marquette Univ.,MILWAUKEE, WI; 4McConnell Brain Imaging Ctr., McGill Univ., Montreal, QC, Canada; 5Med. Col. ofWisconsin, Milwaukee, WIAbstract: Recent work has shown that, during uncomplicated locomotor behaviors such as walking and pedaling, thesensory and motor cortices of the human brain are more active than previously thought. However, thefunction of these structures is unclear. Some studies suggest that the primary motor cortex (M1)contributes directly to locomotor muscle output. Others indicate that M1 activity during locomotionrepresents sensory feedback from the moving limbs. In this study we used magnetoencephalography(MEG) to examine human brain activity in the sensory and motor cortices during pedaling. Wehypothesized that, if these brain regions are important for controlling locomotion, then the MEG signalwould be different during pedaling as compared to rest and would be modulated with the phase of thepedaling cycle. Moreover, if locomotor-related brain activity is caused solely by sensory feedback, then theMEG signal would be the same during active and passive pedaling.Eight individuals pedaled while lying supine on a MEG scanner bed. MEG scans were performed duringthree conditions: rest, active pedaling, passive pedaling. Distributed source modeling was used todetermine the cortical origins of task-dependent neural activity. Four regions of interest were examined:M1, primary sensory cortex, premotor area, supplemental motor area. For each region and each condition,we examined the mean power of the MEG signal in the alpha, beta, and gamma frequency bands. Wealso examined modulation of beta band power across the pedaling cycle.Mean power decreased during pedaling as compared to rest in the alpha and beta bands, but not in thegamma band. This decrease in power was evident during active and passive pedaling. Beta band powerwas modulated across the pedaling cycle. During active and passive pedaling, deep fluctuations in betapower were observed at approximately twice the pedaling frequency. These fluctuations were likely relatedto the phase of the pedaling cycle, as similar fluctuations were not apparent during rest. Phase-dependentmodulation of beta power was larger during passive as compared to active pedaling. All of theseobservations were evident in all four regions of interest.Results suggest that the sensory and motor cortices of the human brain contribute to locomotor-likemovements. Changes in beta power across the pedaling cycle suggest that activity in the brain regionsexamined may help shape the phasic pattern of muscle activity that is characteristic of locomotion.Differences in beta power modulation during active and passive pedal suggest that the sensory and motorcortices may be involved in motor output and sensory processing during locomotion.Disclosures:  S.M. Schindler-Ivens: None. R. Swedler: None. B. Schmit: None. S. Baillet: None.Keyword(s): WALKINGMEGIMAGINGSupport: NICHD-MCMRR (K01HD00600693)[Authors]. [Abstract Title]. Program No. XXX.XX. 2012 Neuroscience Meeting Planner. New Orleans, LA:Society for Neuroscience, 2012. Online.2012 Copyright by the Society for Neuroscience all rights reserved. Permission to republish any abstract orSimple Search  Search Tips    Display As SessionPresentationIMPORTANT: Pleaseremember to create anew itinerary accountfor this year beforeadding items to youritinerary.Note: When addingitems to your Itinerary,please click "AddChecked Selections toMy Itinerary" on EACHpage of your searchresults.About the MeetingSessions/EventsRegistrationHotel/TravelExhibitsAttendee ResourcesAbstractsFellowships, Awards,and PrizesFrequently AskedQuestionsFinal ProgramCMEDownload Abstracts andDaily Books (updated10/13/2012) to Your E-Reader DevicesOASISfile:///I|/Projects/IR/Faculty_Students/College_Health-Sciences/Schindler-Ivens/ViewAbstract.aspx.htm[1/3/2013 11:55:36 AM]part of any abstract in any form must be obtained in writing by SfN office prior to publication.OASIS Technical Support.Monday - Friday, 9 am - 5 pm CTPhone: 1-217-398-1792Email: OASIS HelpdeskLeave OASIS Feedback Leave OASIS FeedbackLeaveOASIS FeedbackThe Online Abstract Submission and InvitationSystem© 1996 - 2013 Coe-Truman Technologies, Inc.All rights reserved.

Neuromagnetic Activity in the Cerebral Cortex is Modulated by Locomotor-Like Movements Produced during Pedaling

https://epublications.marquette.edu/cgi/viewcontent.cgi?article=1022&amp;context=phys_therapy_fac

Neuromagnetic Activity in the Cerebral Cortex is Modulated by Locomotor-Like Movements Produced during Pedaling

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