Studies on the Preparation of Protomycinolide IV: Enantioselective Synthesis of the C3–C9 Segment

Abstract

The C3–C9 segment, (−)-16, of the polyene macrolide antibiotic protomycinolide IV (1a) was prepared in optically pure form from commercially available methyl (S)-2-methyl-3-hydroxypropionate in 12 steps giving 17% yield