Synthesis of (2-carboxycyclopropyl)glycines via Organoiron Methodology

Abstract

(2-Carboxycyclopropyl)glycines (CCGs) were shown to be useful compounds for-studies of glutamate neurotransmission in the mammalian central nervous system(CNS). This is due to their structural similarity to glutamic acid, one of the most common neurotransmitters, and their selectivity towards specific subtypes of glutamate receptors. This selectivity is associated with conformational rigidity of these compounds and allows for mapping of binding sites of the receptors. Development of new analogs of CCGs could provide a deeper knowledge of the mechanisms and requirements for binding in the glutamate receptors. The goal of this thesis is to develop a novel, simplified method for synthesis of CCG analogs using organometallic methodology