This report describes the diagnosis and prosthodontic management of 2 patients with a history of chronic gastroesophageal reflux disease and worn dentition. Different treatment approaches were used for oral rehabilitation. Use of conventional and contemporary restorative materials resulted in functional and esthetic prosthodontic rehabilitation with a favorable prognosis. Gastroesophageal reflux disease (GERD) is a “condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications. Reflux episodes can be intensified by dietary habits, smoking, physical exercise, and obstructive sleep apnea.Complications of GERD are regurgitation, chest pain, esophagitis, Barrett’s esophagus, esophageal adenocarcinoma, cough, asthma, and dental erosion.GERD is associated with dental erosion and sleep bruxism,and dental erosion may be the only symptom of GERD. The purpose of this report was to present the oral diagnosis and management of 2 patients with chronic GERD who presented with tooth wear and required complete mouth rehabilitation. The restoration of dentition was achieved by following different treatment modalities