In the present study the authors examined the relative contributions of typical acculturation indicators, general coping, and intercultural competence in predicting depression among 96 Hispanic adults. The results indicated that intercultural competence served to moderate the relationship between acculturation and depression. The combination of high acculturation and high intercultural competence was associated with fewer symptoms. General coping accounted for significant amounts of variance in predicting depression, over and above traditional acculturation variables alone, suggesting that an active problemsolving style was associated with a healthier outcome. The findings are discussed within the context of integrating competence-based variables into psychological conceptualizations of cultural adaptation and the importance of group-specific abilities as potential buffers against negative mental health consequences