Abeni, D

Di Pietro, C

Paradisi, A

Sampogna, F

Tabolli, S

Uras, C

Zambruno, G

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PR4 QUALITY OF LIFE IN PATIENTS WITH EPIDERMOLYSIS BULLOSA 

Rio Abstracts A485
Symptoms Score (IPSS). 44 articles which used the IPSS were able to detect a signiﬁcant 
change in the symptom scores. The remaining articles used various other PRO mea-
sures for their BPH endpoints. Of the 70 articles yielded from the Phase II search, 11 
were utility studies, 25 were BPH-speciﬁc articles, 29 were overactive bladder (OAB)-
speciﬁc articles, and 5 were urge urinary incontinence (UUI)-speciﬁc articles. From the 
BPH, OAB, and UUI articles, we identiﬁed the key QOL instruments utilized to 
measure the various domains key to BPH. CONCLUSIONS: There have been a large 
number of PRO measures used in the literature to study BPH and related endpoints. 
It is clear that the IPSS has been used in the majority of the studies focused on BPH 
symptoms (81.25% of the ones reviewed).
PR2
IMPROVEMENT IN WORKPLACE AND HOUSEHOLD PRODUCTIVITY 
FOR PATIENTS WITH EARLY RHEUMATOID ARTHRITIS TREATED 
WITH ADALIMUMAB PLUS METHOTREXATE: WORK OUTCOMES AND 
THEIR CORRELATIONS WITH CLINICAL AND RADIOGRAPHIC 
MEASURES FROM A RANDOMIZED CONTROLLED TRIAL COMPANION 
STUDY
van Vollenhoven R1, Cifaldi M2, Ray S2, Chen N2, Weisman MH3
1Karolinska Institutet, Stockholm, Sweden, 2Abbott Laboratories, Abbott Park, IL, USA, 
3Cedars Sinai Medical Center, Los Angeles, CA, USA
OBJECTIVES: To evaluate work productivity of paid workers and homemakers with 
rheumatoid arthritis (RA) treated with adalimumab plus methotrexate (ADAMTX), 
ADA monotherapy, or MTX monotherapy, and to determine baseline predictors of 
work outcomes. METHODS: Data were from the DE032 companion study to 
PREMIER, a 2-year, randomized controlled trial of MTX-naïve patients with early 
RA (3 years). Absenteeism (number of missed work days), presenteeism (patients’ 
self-judgment of effects of RA on work performance), and employment status data 
were collected from self-reports at baseline and varying timepoints during the 2-year 
study. For analyses of cumulative variables, adjustments were made for duration of 
patients’ participation in DE032. RESULTS: Of 799 patients in PREMIER, 664 par-
ticipated in DE032 (ADAMTX, n  219; ADA monotherapy, n  231; MTX mono-
therapy, n  214). Percentages of paid workers and homemakers were similar across 
treatment groups. Among paid workers, the number of missed work days at Year 2 
was signiﬁcantly fewer for ADAMTX (17.4 days) and ADA monotherapy (18.7 days) 
vs. MTX monotherapy (36.9 days, p  0.0001). Improvement in presenteeism was 
greater with ADAMTX vs. MTX monotherapy (p  0.05 at most visits). The percent-
age of patients who retained or gained employment over the 2-year study was 57.6% 
(121 of 210) for ADAMTX, 51.8% (116 of 224) for ADA monotherapy, and 47.6% 
(100 of 210) for MTX monotherapy. The odds of retaining/gaining employment were 
signiﬁcantly greater for ADAMTX vs. MTX monotherapy (odds ratio [OR]  1.53, 
95% conﬁdence interval [CI]: 1.04–2.26, p  0.032). Retaining/gaining employment 
was signiﬁcantly associated with younger age, female sex, and better baseline scores 
on the Health Assessment Questionnaire, Short Form 36 Health Survey, and radio-
graphic progression (joint space narrowing, joint erosion, total Sharp score). 
 CONCLUSIONS: ADAMTX was associated with more positive work outcomes vs. 
MTX monotherapy. Productivity outcomes were similar for paid workers and home-
makers. Radiographic progression at baseline was predictive of employment status.
PR3
EFFECT OF PREHOSPITALIZATION PERIOD AND TYPE OF PESTICIDES 
ON OUTCOMES IN ACUTE ORGANOPHOSPHORUS POISONING
Rose Xavier V1, Thunga G2, Sam KGS2, Kehra K3
1Manipal University, Udupi, karnataka, India, 2Manipal University, Udupi, Karnataka, India, 
3Manipal Acuova, Udupi, karnataka, India
OBJECTIVES: To study the effect of prehospitalization period and type of pesticides 
on outcomes in acute organophosphorus poisoning METHODS: A prospective study 
was conducted with organophosphate poisoning patients admitted to our emergency 
department between January 2007 and January 2008. Information regarding the age, 
sex, occupation, prehospitalization period, type of agent, route of poisoning, clinical, 
laboratory ﬁndings, type of management and subsequent outcome were recorded from 
the patient medical records. The outcomes were analyzed in terms of percentage of 
intermediate syndrome, requirement of ventilation, duration of hospitalization period, 
percentage of mortality, percentage of sequel and percentage of recovery. The out-
comes were compared with preospitalization period and type of pesticides. RESULTS: 
During the study period, 100 patients were admitted to the emergency ward with acute 
organophosphorus poisoning. The estimated mean prehospitalization period after the 
exposure was 2.5 o 2.1 hours. There were 68 male and 32 female patients. The most 
affected age group was 21–30 years (60%). Oral ingestion (99%) was found to be 
the most common route of poisoning. The most frequent reason for poisoning was 
attempted suicide (98%). The most common organophosphate compounds exposed 
were type Ia which was extremely hazardous (60%) and type II which was moderately 
hazardous (25%).Comparing the outcomes with the mean prehosptalization period 
showed that it did not signiﬁcantly affect outcomes in acute OP poisoning, but the 
incidence of intermediate syndrome was higher in these patients. There was signiﬁcant 
correlation between type of compound and outcome. The incidence of intimidate 
syndrome, requirement for ventilation and rate of mortality was signiﬁcantly higher 
in type Ia compounds when compared to other type of pesticides. CONCLUSIONS: 
The prehospitalization period had no inﬂuence on outcomes in acute OP poisoning, 
where as type of OP compounds signiﬁcantly effect incidence of intimidate syndrome, 
requirement for ventilation and rate of mortality.
PR4
QUALITY OF LIFE IN PATIENTS WITH EPIDERMOLYSIS BULLOSA
Tabolli S, Uras C, Paradisi A, Sampogna F, Di Pietro C, Abeni D, Zambruno G
IDI IRCCS, Rome, Italy
Epidermolysis bullosa (EB) is a rare, inherited group of disorders characterized by 
blistering of the skin following friction or mechanical trauma. EB has a clinical and 
socio-economic impact on patients and their families. OBJECTIVES: To assess the 
Quality of Life (QoL) in patients with EB and to determine disease burden. METHODS: 
The study was an observational, cross-sectional postal survey. 185 patients were 
invited to participate. Different sets of questionnaires (SF-36, Skindex-29, GHQ-12, 
EQ-5D) were sent to patients according to age. The perceived severity of the disease 
was evaluated by patients or by the mothers of the younger EB children, using the 
Patient Global Assessment 5-point scale. Caregivers received the Family Strain Ques-
tionnaire (FSQ). RESULTS: A total of 125 respondents were analysed. EB patients 
showed lower values in physical components of SF-36, while the mental ones were 
not signiﬁcantly impaired. Among EB types, junctional EB and severe generalized 
recessive dystrophic EB patients reported lower values and their General Health scale 
was signiﬁcantly different from EB simplex. There were no signiﬁcant differences 
among EB types/subtypes for Skindex-29 values. Females had a worse QoL compared 
to males in each Skindex-29 and SF-36 scales (p  0.05). GHQpositive cases were 
48% among females, 16% among males (p  0.003); GHQpositive cases had a worse 
QoL compared to GHQnegative. The patient QoL and the family burden increased 
with increasing patient’s perceived disease severity and with increasing patient’s body 
surface involved. No differences were seen among EB types for the family burden. 
CONCLUSIONS: In EB patients mental components of SF-36 scores are similar to 
the normal population. The perceived disease severity and skin area involved are rel-
evant for QoL independently by EB type/subtype. EB imposes a heavy burden on the 
caregiver and the family. Psychological support and close monitoring of QoL may 
help EB patients and their caregivers.
PODIUM SESSION I: RESEARCH ON METHODS: I
MC1
VALORACIÓN SOCIAL DE LOS ESTADOS DE SALUD EQ-5D EN CHILE: 
ALCANCES METODOLÓGICOS
Valenzuela P1, Vignau A1, Olivares-Tirado P2, Muñoz A2, Kind P3, Zarate V3
1Consultor DATAVOZ / STATCOM, Santiago, Chile, 2Superintendencia de Salud, Santiago, 
Chile, 3University of York, York, UK
OBJECTIVOS: Obtener la valoración social de los estados de salud de EQ-5D en una 
muestra representativa de la población de Chile y determinar con ello, el índice social 
EQ-5D de la totalidad de estados de salud de EQ-5D (243). METODOLOGÍAS: Se 
entrevistaron a 2000 personas de 20 años y más, residentes de la Región Metropoli-
tana de Chile, a las que se les aplicó el cuestionario EQ-5D/VAS, recogiéndose además 
datos sobre variables sociodemográﬁcas relevantes. Luego, se evaluaron 42 estados de 
salud mediante los métodos VAS, ranking y equivalencia temporal (TTO). Los 42 
estados de salud utilizados corresponden a los mismos utilizados en el estudio Mea-
surement and Valuation of Health (MVH) del Reino Unido en 1993. RESULTADOS: 
Se obtuvo la valoración para los 42 estados de salud, con las diferentes metodologías 
señaladas. Las tasas de respuesta y niveles de consistencia fueron similares a los 
observados en estudios de países desarrollados. Se observó una diﬁcultad decre- 
ciente en la aplicación de las metodologías- VAS, ranking y TTO. Los resultados 
obtenidos mediante las tres técnicas se encuentran muy correlacionados entre si. 
CONCLUSIONES: La colaboración de la población encuestada y el compromiso del 
equipo de encuestadores, al ceñirse estrictamente a la metodología del estudio, res-
paldan la validez y conﬁabilidad de la información recopilada. Un trabajo de campo 
con énfasis en capacitación y control constante del proceso de recopilación de datos, 
permite reducir la tasa de no respuesta a niveles de países desarrollados. La aplicación 
secuencial de las tres metodologías permite obtener muy buenos resultados tanto en 
consistencia interna como en sus correlaciones.
MC2
SELF-PERCEPTION OF HEALTH IN LATIN AMERICA
Cabieses Valdes B1, Espinoza MA2, Zarate V3
1Universidad del Desarrollo, Santiago, RM, Chile, 2Pontiﬁcia Universidad Catolica de Chile, 
Santiago, RM, Chile, 3University of York, York, North Yorkshire, UK
OBJECTIVES: The capacity for planning and implementing public health policies 
requires knowledge and understanding of population’s health status. Information 
traditionally collected in population surveys is related to physical and biological mea-
surements; however, the self-perception of health has recently gained importance. This 
has occurred in light of the widespread phenomenon of an aging population and 
increased prevalence of chronic diseases and disabilities at international level. The 
study compared the self-perception of health-related quality of life (HrQoL) of six 
Latin American countries and its relationship with socio-demographic variables. 
METHODS: This study was based on secondary data collected for World Health 
Survey 2005. Participating countries in the region were Brazil, Paraguay, Uruguay, 
Mexico, Dominican Republic and Ecuador. A probabilistic sample was collected for 
each country, with sex and age national representation (n  67,734). The study 
outcome was HrQoL classiﬁed in 5 categories (Very Good, Good, Moderate, Bad, 
Very Bad). Analyses to estimate the existence of real differences on overall HrQoL 
between countries were performed through binary and ordinal logistic regressions. 
Results were adjusted by sex, age and educational level. RESULTS: The two countries 


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PR4 QUALITY OF LIFE IN PATIENTS WITH EPIDERMOLYSIS BULLOSA

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