Cao Zhen-Bo

Higuchi Mitsuru

Ise Ryuuken

Oshima Satomi

Sun Xiaomin

Tanisawa Kunpei

Torii Suguru

Oshima, Satomi

Ise, Ryuuken

Sun, Xiaomin

Tanisawa, Kunpei

Cao, Zhen-Bo

Torii, Suguru

Higuchi, Mitsuru

Waseda University Repository

スポーツ科学研究, 11, 35-68, 2014 年 53  Intrahepatic triglycerides is associated with insulin sensitivity in male athletes: MR imaging and spectroscopy study  Satomi Oshima1, Ryuuken Ise2, Xiaomin Sun2, Kunpei Tanisawa2, Zhen-Bo Cao1,  Suguru Torii1, Mitsuru Higuchi1 1Faculty of Sport Sciences, Waseda University  2Graduate School of Sports Sciences, Waseda University  The purpose of this study was to examine how intrahepatic triglycerides (IHCL), visceral fat (VF), and total body fat mass (FM) are correlated with insulin sensitivity in male athletes who regularly participates in overfeeding and high intensity exercise.   Subjects were thirty-three college male American football and Rugby players aged 19-23 years. Body composition was measured by DXA. Insulin sensitivity was measured by oral-glucose tolerance test (OGTT) expressed as area under the curve (AUC) for glucose and insulin responses. IHCL was measured using noninvasive 1H-magnetic resonance spectroscopy and VF was measured by magnetic resonance imaging. Positive correlations were observed between insulin AUC with IHCL (r=0.681, p<0.001) and VF (r=0.405, p<0.019). The correlation between insulin AUC and FM (r=0.342, p=0.051)  was weaker compared to its correlation with IHCL or VF. Among these fat stores, only IHCL was the independent predictor of insulin sensitivity (β=0.681, p<0.001), according to the multiple regression analysis. Notably, IHCL is a much stronger predictor than with VF or FM for insulin sensitivity.  In conclusion, these results suggested that hepatic triglycerides accumulation has important consequence that may adversary affect insulin sensitivity even in trained athletes.               

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Intrahepatic triglycerides is associated with insulin sensitivity in male athletes: MR imaging and spectroscopy study

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Intrahepatic triglycerides is associated with insulin sensitivity in male athletes: MR imaging and spectroscopy study

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