Badridze, N.

Dvali, N.

Dzigua, L.

Gatserelia, L.

Karchava, M.

Sharvadze, L.

Tsertsvadze, T.

International Journal of Infectious Diseases

Elsevier - Publisher Connector 

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ltrasonography changes of the liver of patients infected
ith hepatitis C met in the Foundation of Tropical
edicine of Amazonas
.R.D.T. Leao1,∗, M. Brock2, R.A.C. Carvalho3, W.S.M.
raga4
Universidade do Estado do Amazonas - Fundac¸ão de Medic-
na Tropical do Amazonas, Manaus, AM, Brazil
Universidade do Estado do Amszonas - Fundac¸ão de Medic-
na Tropical do Amazonas, Manaus, AM, Brazil
Universidade do Estado do Amazonas - Fundac¸ão de Medic-
na Tropical do Amazonas, manaus, Brazil
Fundac¸ão de Medicina Tropical do Amazonas, Amazonas,
razil
Background: 50% to 85% of the patients infected by hep-
titis C virus will develop a chronic infection, 20% of them
ill suffer from cirrhosis and 1% to 4% will develop hepa-
ocellular carcinoma. Morfologic and hemodynamic changes
hich occur in the liver and in the portal system can be
valuated by Doppler ultrasonography at an early stage and
n a non-invasive way.The main purpose of this paper was
o study alterations detected by ultrasonography examina-
ions in hepatitis C patients assisted at Fundac¸ão de Medicina
ropical do Amazonas.
Methods: In an 8-month period, 50 patients anti-HCV pos-
tive whose ages ranged from 18 to 69 were submitted to
oppler ultrasonography examinations.
Results: Most of the patients were males (74%) at an
verage age of 47,1. Morfologic alterations were detected,
uch as increase of the volume of the liver (12%) mainly
n the left liver lobe, increase of liver ecogenicity (24%),
splenomegaly (14%) and increase of ecogenicity and gall-
ladder wall thicknen (4%).
Conclusion: Hemodynamic alterations were noticed,
ostly a reduction on the portal vein velocity (26%), alter-
tions on the congestion index (12%), on the vascular hepatic
ndex (16%) and impedance of hepatic and splanchinic arte-
ial index.
oi:10.1016/j.ijid.2010.02.2013
3.032
etection of acute HCV infection among different risk
roups
. Gatserelia ∗, L. Sharvadze, M. Karchava, N. Dvali, L.
zigua, N. Badridze, T. Tsertsvadze
Infectious Diseases, AIDS and Clinical Immunology Research
enter, Tbilisi, Georgia
Background: To investigate acute HCV infection from the
ery ﬁrst days of the infection among blood donors, inject-
ng drug users (IDUs), health care workers and persons who
ad ﬁrst life time sexual intercourse with the chronic HCV
nfected persons in orders to asses clinical laboratory vari-
nts of infection, viral replication kinetic, disease outcome.Methods: Study was performed among ELISA negative
ersons in four groups: 7500 blood donors, 3200 IDUs, 70
xposed health care workers and 45 persons who had ﬁrst
ife time sexual intercourse with the chronic HCV infected
m
H
e
aternational Congress on Infectious Diseases (ICID) Abstracts
ersons. All groups were investigated on HCV RNA by Real
ime PCR (COBAS TaqMan Roche) using pool method and
enotyped by line probe assay (Innolipa, Versant, Bayer)
ccording to the manufacturer’s instructions. The results
ere analyzed by age, sex, duration of infection, modes of
ransmission and other variables.
Results: Total of 21 patients with acute HCV infection
ere identiﬁed: 7 from blood donors, 9 from IDUs, 1 from
ealth care workers and 4 from persons who had ﬁrst
ife time sexual intercourse with the chronic HCV infected
atients. All HCV RNA positive persons revealed within the
tudy were followed on viral load dynamic at detection
oment and at 2, 4 and 8 weeks and after 3 and 6 months
rom their possible exposure. Among them: 5 were symp-
omatic and 16 asymptomatic. Among 21 subjects: 10 had
enotype - 1b, 5 - 2a/2c and 6 - 3a. Out of 21 patients 7
leared the virus (5 were symptomatic: 1 - genotype 1b, 2
genotype 2a/2c, 2 - genotype 3a, and 2 asymptomatic:
- genotype 1b, 1 - genotype 3a), while 14 developed
hronic infection. In all patients viremia increased rapidly
nd reached a peak by week 4. After week 10 the viremia
apidly decreased. It became either undetectable by weeks
6-18 (viral clea rance), or virus was not eliminated (chronic
nfection).
Conclusion: We found that HCV viral clearance was cor-
elated with high viral titers, symptomatic form of disease
nd sexually transmitted HCV infection in female subjects.
tudy revealed no correlations between viral genotype and
iral clearance rates.
oi:10.1016/j.ijid.2010.02.2014
3.033
fﬁcacy of 96 weeks adefovir dipivoxil treatment in
BeAg positive chronic hepatitis B patients with various
aseline biochemical levels
. Zhuang1,∗, J. You2, L. Kong1, H. Lei1, R.-D. Yang2, X.
hang2, Q.-Q. Wang2
Third Municipal People’s Hospital of Kunming, Kunming,
hina
The First Afﬁliated Hospital of Kunming Medical Univer-
ity, Kunming, China
Background: Adefovir dipivoxil (ADV) has shown efﬁcacy
nd safety in a broad range of populations with chronic
epatitis B over 48 to 96 weeks. This study reports the
6-week long-term efﬁcacy data with ADV treatment in
ucleoside-naive HBeAg-positive chronic hepatitis B patients
ith various baseline biochemical levels.
Methods: Ninety-eight HBeAg-positive patients who had
ever received nucleoside treatment received 96-week ADV
0mg/d therapy. All patients had serum level of HBV load
ver 105 copies/ml and increased serum alanine aminotrans-
erase (ALT) level. Based on serum ALT levels at baseline,
ll patients were divided into two groups, A (48 patients
ith serum ALT level less than 200U/L) and B (50 patients
ith ALT level more than 200 U/L). Serum HBV load was
easured with quantitative real-time-PCR. ALT activity,
BeAg, anti-HBeantibodies, HBV-DNA level in serum were
valuated at baseline, week 12, 24, 48 and 96 during ther-
py.


Detection of acute HCV infection among different risk groups 

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Detection of acute HCV infection among different risk groups

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