Antibacterial susceptibility of new copper(II) N-pyruvoyl anthranilate complexes against marine bacterial strains – In search of new antibiofouling candidate

Abstract

AbstractBiofouling is a serious problem and very difficult to overcome, since the marine biofilm-producing microorganisms resist the host defense mechanism and antibiotic therapy. Therefore, there is an urgent need to develop potent anti-biofouling agent to effectively eradicate unwanted biofilms. Our work represents antibacterial susceptibility and antibiofilm forming assay of new copper(II) N-pyruvoyl anthranilate architectures (4a–d) against Staphylococcus aureus and Escherichia coli, marine isolates. The preliminary biofilm susceptibility tests revealed that, the most potent staphylococcalcidal (MIC/MBC=9.25/10.50mM) and E. coli-cidal (MIC/MBC=13.25/13.50mM) agent, 4d, exhibits significant biofilm inhibition. Complex 4d can therefore provide an antibiofilm-forming agent candidate to curb the formation of biofilms