Annois, Brigitte

Cutajar, Jennifer

Itsiopoulos, Catherine

Kelly, Jaimon T

Marshall, Skye

Marx, Wolfgang

Pipingas, Andrew

Tierney, Audrey C

English

Background: Due to the increasing burden of age-relatedcognitive decline, interventions that can improve cognitiveperformance are of interest. Resveratrol, a plant derivedpolyphenol, has been reported to improve cognitiveperformance in animal models and has recently beeninvestigated in several clinical trials. The aim of this systematicreview was to evaluate clinical trial data regarding the effect ofresveratrol on cognitive performance.Methods: In accordance with PRISMA guidelines, a systematicliterature review and meta-analysis was conducted using thefollowing databases: MEDLINE, CINAHL, Cochrane, EMBASEand Proquest. Studies included in this review stipulated thatthe independent variable was resveratrol and used outcomemeasures of cognitive performance. A meta-analysis wasconducted to determine treatment effect on the followingcognitive domains and mental processes: processing speed,number facility, mood, and memory. Risk of bias was assessedusing the Cochrane Collaboration Risk of Bias tool; and qualityof the body of evidence assessed by GRADE.Results: Ten clinical trials were included. Three studiesreported resveratrol to significantly improve some measuresof cognitive performance, two reported mixed findings, andfive reported no effect. When data was pooled, resveratrolsignificantly improved delayed recognition, a measure ofworking memory (SMD 0.39 [95% CI 0.08, 0.70]; I2=0%;p=0.01; n=3 studies; n=166 participants; GRADE level:moderate) and negative mood (SMD -0.18 [95% CI -0.31,-0.05]; I2=0%; p=0.006; n=3 studies; n=163 participants;GRADE level: moderate). Included studies generally hadlow risk of bias and study outcomes were of moderateor high quality. There was considerable heterogeneity inthe methodology of the included studies regarding theintervention length, and participant age and disease statusConclusion: The results of this systematic review indicatethat resveratrol might improve select measures of cognitiveperformance; however, the current literature is inconsistent.Future studies are recommended to focus on long-termsupplementation and adjustment for existing limitations suchas dietary polyphenol intake

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The effect of resveratrol on cognitive performance: a systematic literature review and meta-analysis

https://pure.bond.edu.au/ws/files/30103029/AuSPEN_Conference_Program_and_Abstracts.pdf

The effect of resveratrol on cognitive performance: a systematic literature review and meta-analysis

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