Black Jr., Asa C

Black, Gypsy F.

Coleman, Julie

Hawkins, Kristina C

Limnios, Jason Ionnis

Lochner, Frank

McCommon, George

Young, Henry E.

English

Stage-specific antigen-4 (SSEA-4) positive cells and carcinoembryonic antigen-cell adhesion molecule-1 (CEACAM-1)positive cells, indicative of pluripotent stem cells and totipotent stem cells, respectively, have beenisolated and characterized from the skeletal muscle and blood of adult animals, including humans. The currentstudy was undertaken to determine their location in the dermis and underlying connective tissues of the adult pig.Adult pigs were euthanized following the guidelines of Fort Valley State University’s IACUC. The skin (epidermisthrough hypodermis) was harvested, fixed, cryosectioned, and stained with the two antibodies: SSEA-4 and CEACAM-1.SSEA-4 positive cells were located preferentially in the reticular dermis of the skin and to some extentin the underlying hypodermis. In contrast, CEA-CAM-1 positive stem cells were preferentially located within thehypodermis of the pig skin within the loose fibrous connective tissues surrounding adipose tissue. CEA-CAM-1positive cells were also located, to a lesser extent, in the dermis as well. These results demonstrate the presence ofnative populations of pluripotent stem cells and totipotent stem cells within the dermis, hypodermis, and adiposetissue of adult pig skin. Studies are ongoing to address the functional significance of these cells in normal injuryand repai

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Healing cells in the dermis and adipose tissues of the adult pig

https://pure.bond.edu.au/ws/files/25941649/healing_cells_in_the_dermis_and_adipose_tissues_of_the_adult_pig_105.pdf

Healing cells in the dermis and adipose tissues of the adult pig

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