An important stage in the preparation of measures to improve the institutional environment in the region is the assessment of the relationship between the establishedі іnstitutions and economic effects derived from their implementation and functioning. Understanding the importance of the development of small and medium-sized businesses by the country's leadership has attracted the formation of goals and principles of state policy in the field of small and medium-sized businesses. Development of the Institute entrepreneurship is one of the priority directions of development of the Ukrainian economy, in particular its regions. It is the development of methodological tools for assessing the impact of entrepreneurs on socio-economic development of the region and its testing. During the research used retrospective, logical, systemic and complex analysis, the method of typology construction, classification, as well as specific methods. Research in the field of institutional analysis and regional economics. Development of methodological evaluation tools influence of institutions on the socio-economic development of regions, allowed to conclude that the Dnipropetrovsk, Transcarpathian, Zhytomyr and Lviv regions in the pre-crisis period were identical in status institutional environment and socio-economic development. But due to different institutional policies of the regions, they become more alternative to each other. Using the proposed methodology in the regions showed that, despite the high degree of similarity institutional environment and the dynamics of socio-economic development, the economy of the regions in different ways reacted to the negative impact caused by the crisis. It found reflection in the change in the values of the similarity coefficients institutional environment and the dynamics of socio-economic development regions. This technique allows us to determine the dependence of dynamics socio-economic development of the region from its institutional environment
