Badretdinova, V. T.

Chernova, Anna Pavlovna

Serykh, T. A.

Electronic archive of Tomsk Polytechnic University

 Секция 7.  Химия и химическая технология на иностранном языке (английский)2272.  Regulation  (EU)  2020/741  of  the  European Parliament and of the Council of 25 May 2020 on minimum requirements for water reuse. Off. J. Eur. Union. L 177, 32–55. 3.  ČSN  75  7143.  Jakost  vod  –  Jakost  vody  pro závlahu, příloha 1, tabulka 1. 1992.4.  Azaïs A., Mendret J., Gassara S., Petit E., De-ratani A. & Brosillon S. (2014). Nanofiltration for  wastewater  reuse:  counteractive  effects  of fouling  and  matrice  on  the  rejection  of  phar-maceutical  active  compounds.  Separation  and Purification Technology, 133, 313–327.5.  Lees K., Fitzsimons M., Snape J., Tappin A., & Comber S. (2016). Pharmaceuticals in soils of lower income countries: Physico-chemical fate and risks from wastewater irrigation. Environ-ment international, 94, 712–723.FUNDAMENTAL RESEARCH OF THE PROCESSES OF BONE TISSUE FORMATION IN THE PRESENCE OF OPTICALLY ACTIVE ORGANIC MOLECULEST.A. Serykh, V.T. Badretdinova1, A.P. Chernova2Scientific supervisor – Ph.D. in Chemistry, associate research professor S.A. Ulasevich1ITMO University Russia, St Petersburg, Lomonosova St.,9, itmo.ru2Tomsk Polytechnic University Russia, Tomsk, Lenin, 30, tpu.ruAmino acids play an important role in the for-mation of natural objects. They create chiral objects with the anisotropy of properties. The amino acids also stabilize the structures of phosphates involved in the biomineralization process. Moreover, the co-precipitation of calcium phosphates and amino acids contributes to the local delivery of materials that enhance cell growth [1–3]. Тhe aim of our research is to study of the bio-compatibility of different cell lines and Liesegang rings in the presence of optically active organic molecules. The object of the study was C2C12 cells cultured with DMEM (Dulbecco's Modified Eagle's Medium) containing glutamine and glucose at a concentration of 1 g/ml with the addition of 10 % of fetal bovine serum and a mixture of antibiotics penicillin and streptomycin.The C2C12 cells were seeded on the obtained samples. There were samples with L-glutamic and L-ascorbic acids, also, for comparison, the cells were seeded on samples without additives. Prolif-eration of C2C12 on the surface of calcium phos-phates in different samples is shown in Figure 1.The cells were calculated by ANOVA, p < 0.1 The data obtained are shown in Figure 2.Fig. 1.  Proliferation of C2C12 on the surface of calcium phosphates patterns during 5 days of cultivationТом 2 XXII Международная конференция «Химия и химическая технология в XXI веке»228It was found that the rings formed with α-amino acids are destroyed after 3 days when cultured with C2C12 cells, while the control (rings formed from calcium phosphates without additives) remains sta-ble. Moreover, L-ascorbic and L-glutamic acids cause a change in their shape towards more elon-gated cells and their more intensive growth, which is likely to contribute to directed cell differentiation.Authors acknowledge RSF grant № 19-79-10244.References1.  Hood  M.A.,  Landfester  K.,  &  Muñoz-Espí  R. (2014). The Role of Residue Acidity on the Sta-bilization of Vaterite by Amino Acids and Oli-gopeptides.  Crystal  Growth  &  Design,  14(3), 1077–1085. doi:10.1021/cg401580y.2.  Ustriyana P., Harmon E., Chen K., Michel F.M., &  Sahai  N.  (2020).  Oligo(L-Glutamic  Acids) in  Calcium  Phosphate  Precipitation:  Chain Length Effect. The Journal of Physical Chemis-try B. doi:10.1021/acs.jpcb.0c01689.3.  Habraken  W.,  Habibovic  P.,  Epple  M.,  & Bohner M. (2016). Calcium phosphates in bio-medical applications: materials for the future? Materials  Today,  19(2),  69–87.  doi:10.1016/j.mattod.2015.10.008.STRUCTURAL FEATURES AND LUMINESCENT PROPERTIES OF LANTHANIDE COMPLEXES WITH ENAMINEDIONE DERIVATIVESK.S. SmirnovaScientific supervisor – PhD, senior researcher E.V. LiderLinguistic advisor – PhD, senior researcher E.V. LiderNikolaev Institute of Inorganic Chemistry SB RAS 630090, Russia, Novosibirsk, 3, Academic Lavrentiev Avenue, smirnova_ksenya96@mail.ruLanthanide coordination compounds are in-teresting because of their pronounced luminescent properties. Upon the impact of the direct excitation, the intense emission of lanthanide-based materials is rarely observed due to forbiddance of f-f transi-tions. Therefore, in the synthesis of complexes, or-ganic molecules are used as ligands, which are ca-pable to absorb the light well and transfer energy to a metal ion with subsequent emission. The mecha-Fig. 2.  Сell density in different regions of the obtained samples after 5 days of cultivation

Fundamental research of the processes of bone tissue formation in the presence of optically active organic molecules

http://earchive.tpu.ru/bitstream/11683/67758/1/conference_tpu-2021-C27_V2_p227-228.pdf

Fundamental research of the processes of bone tissue formation in the presence of optically active organic molecules

Abstract

Similar works

Full text

Available Versions

Electronic archive of Tomsk Polytechnic University