Baulin, A. A.

Sukhikh, Evgeniya Sergeevna

Sukhikh, Leonid Grigorievich

English

Electronic archive of Tomsk Polytechnic University

XIII International Symposium RREPS-19, 15-20 September 2019, Belgorod, Russia 95Dose-Enhancing Agent for Radiotherapy at OrthovoltageX-Rays IrradiationA.A.Baulina,b,1, E.S.Sukhikhc,a, L.G.Sukhikhaba National Research Tomsk Polytechnic University, Tomsk, Russiab Gamma Clinic High-Precision Radiology Centre (Gamma Medtechnology Ltd), Obninsk, Russiac Tomsk Regional Oncology Centre, Tomsk, RussiaPhoton-capture therapy (PCT) or contrast-enhanced radiotherapy (CERT) is apromising development direction of binary radiation therapy, which is applied inorder to increase the treatment efficiency that may be caused by the local energydeposition in the tumor [1]. The basic principle of PCT is the generation of alarge number of the characteristic X-rays and low-energy Auger-electrons due tointeraction between photons and nuclei of heavy elements (Z ≥ 53). In biologicaltissue this secondary low-energy radiation ionizes nearby atoms and leads to theoccurrence of highly active radical series, which causes the destruction of themacromolecules of DNA and RNA as well as other cell structures[2].The results of previous radiobiological studies based on orthovoltage X-raysirradiation have shown that the presence of cisplatin (Pt, Z = 78) reduces thesurvival of the HeLa cells[3].The purpose of this research is to study and evaluate the dependence of doseincrease on DEA concentration at orthovoltage X-rays radiation using Monte-Carlo simulation methods.As part of this study the simulation of 60, 120, 180, 250 keV photon beamsat different concentrations cisplatin in tumor volume was simulated by Geant4and Computer Lab (PCLab). At the first stage of this research we performedsimulation of dose distribution in the water (Blue Phantom) from Xstral300 X-ray tube that was previously measured at Tomsk Regional Oncology Centre. Inthe second stage we performed simulation of dose depth curves in the presence ofcisplatin in the target volume. Cisplatin concentrations from 3 µM to 0.03M werestudied. 3 µM concentration is the minimal concentration, which had a visibleeffect during the radiobiological experiments [3]. The simulation results showedthat the dose escalation can be caused by PCT. There is a dose enhancementin the volume where cisplatin is accumulated. The higher is concentration, thehigher is the effect. However, the photon energy increase from 60 to 250 keVand increase of depth of target reduces the effect of PCT due the decrease of thephotoelectric effect cross-section.References[1] V.F.Hohlov, V.N.Kulakov, I.N.Sheino, et al. Method of photon-capture therapy of tumors //Burnazyan FederalMedical Biophysical Center. 2006. RU Patent No.2270045.[2] I.N.Sheino, P.V.Izhevskij, A.A.Lipengolts, et al. Development of binary technologies of radiotherapy of malignantneoplasms: condition and problems //Bulletin of Siberian Medicine. 2017. V.16(3). P.192-209.[3] A.A.Baulin, E.S.Sukhikh, S.A.Vasilyev, et al. Study of HeLa cells clone survival after X-ray irradiation in the presenceof cisplatin //AIP Publishing. 2017.Рғ.020005-1 - 0200055-4.1 Corresponding author: baulin.91@mail.ru

Dose-Enhancing Agent for Radiotherapy at Orthovoltage X-Rays Irradiation

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Dose-Enhancing Agent for Radiotherapy at Orthovoltage X-Rays Irradiation

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