The article gives the definition of the local cluster as a spatial and sectoral concentration of interconnected companies, the end product or service that is exported outside of the local territorial entity. The cluster approach of solving the problems of economic development of the Siberian region is reflected in the "Strategy of socio-economic development of Siberia till 2020". It summarizes the experience of formation of high-tech clusters in Siberia. Marked economic perspective directions of clustering region. Tomsk region is marked as a regional with a great innovative potential in forming clusters and other innovative structures. The basic problems in the way of implementation of the cluster approach and related institutional changes in the economy are identified