Supplemental Figures. 3D PDF CS14, CS16, CS20, CS23, and 9.0 and 9.5 WKS. Interactive 3D PDFs are provided for CS14, CS16, CS20, CS23, and 9.0 and 9.5 WKS. See the supplement â3D PDF operation manualâ for instructions how to use the interactive PDF tools. The color codes correspond to those used in the Figures (Legend Table). (PDF 394 kb

Hayelom K. Mekonen

Jelly HM Soffers

Jill PJM Hikspoors

S. Eleonore Koehler

Wouter H. Lamers

BMC Developmental Biology

PubMed

It remains unclear to what extent midgut rotation determines human intestinal topography and pathology. We reinvestigated the midgut during its looping and herniation phases of development, using novel 3D visualization techniques. We distinguished 3 generations of midgut loops. The topography of primary and secondary loops was constant, but that of tertiary loops not. The orientation of the primary loop changed from sagittal to transverse due to the descent of ventral structures in a body with a still helical body axis. The 1st secondary loop (duodenum, proximal jejunum) developed intraabdominally towards a left-sided position. The 2nd secondary loop (distal jejunum) assumed a left-sided position inside the hernia before returning, while the 3rd and 4th secondary loops retained near-midline positions. Intestinal return into the abdomen resembled a backward sliding movement. Only after return, the 4th secondary loop (distal ileum, cecum) rapidly "slid" into the right lower abdomen. The seemingly random position of the tertiary small-intestinal loops may have a biomechanical origin. The interpretation of "intestinal rotation" as a mechanistic rather than a descriptive concept underlies much of the confusion accompanying the physiological herniation. We argue, instead, that the concept of "en-bloc rotation" of the developing midgut is a fallacy of schematic drawings. Primary, secondary and tertiary loops arise in a hierarchical fashion. The predictable position and growth of secondary loops is pre-patterned and determines adult intestinal topography. We hypothesize based on published accounts that malrotations result from stunted development of secondary loop

Soffers, Jelly H. M.

Hikspoors, Jill P. J. M.

Mekonen, Hayelom K.

Koehler, S. Eleonore

Lamers, Wouter H.

NARCIS 

The growth pattern of the human intestine and its mesentery

BACKGROUND: It remains unclear to what extent midgut rotation determines human intestinal topography and pathology. We reinvestigated the midgut during its looping and herniation phases of development, using novel 3D visualization techniques. RESULTS: We distinguished 3 generations of midgut loops. The topography of primary and secondary loops was constant, but that of tertiary loops not. The orientation of the primary loop changed from sagittal to transverse due to the descent of ventral structures in a body with a still helical body axis. The 1st secondary loop (duodenum, proximal jejunum) developed intraabdominally towards a left-sided position. The 2nd secondary loop (distal jejunum) assumed a left-sided position inside the hernia before returning, while the 3rd and 4th secondary loops retained near-midline positions. Intestinal return into the abdomen resembled a backward sliding movement. Only after return, the 4th secondary loop (distal ileum, cecum) rapidly "slid" into the right lower abdomen. The seemingly random position of the tertiary small-intestinal loops may have a biomechanical origin. CONCLUSIONS: The interpretation of "intestinal rotation" as a mechanistic rather than a descriptive concept underlies much of the confusion accompanying the physiological herniation. We argue, instead, that the concept of "en-bloc rotation" of the developing midgut is a fallacy of schematic drawings. Primary, secondary and tertiary loops arise in a hierarchical fashion. The predictable position and growth of secondary loops is pre-patterned and determines adult intestinal topography. We hypothesize based on published accounts that malrotations result from stunted development of secondary loops

Soffers, J.H.

Hikspoors, J.P.

Mekonen, H.K.

Koehler, S.E.

Lamers, W.H.

Crossref

Maastricht University Research Portal

Springer - Publisher Connector

Jelly Soffers (3552953)

Jill Hikspoors (3552944)

Hayelom Mekonen (3552941)

S. Koehler (3552950)

Wouter Lamers (3552947)

The Francis Crick Institute

Additional file 1: of The growth pattern of the human intestine and its mesentery

The growth pattern of the human intestine and its mesentery

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Maastricht University Research Portal

Springer - Publisher Connector

The Francis Crick Institute

Maastricht University Research Portal