Tissue mass-normalized values of cytochrome C reduced in vitro by succinate dehydrogenase from homogenized TAs of VEH- or RAPA-treated LC and KO mice. Two-way ANOVA. (PDF 291 kb

Aaron M. Beedle

Ankit Patel

Jarrod A. Call

Junna Luan

Kristen B. Peissig

Marisa J. Fortunato

Steven J. Foltz

Skeletal Muscle

Steven Foltz (3543443)

Junna Luan (845138)

Jarrod Call (3543437)

Ankit Patel (774246)

Kristen Peissig (3543440)

Marisa Fortunato (3543446)

Aaron Beedle (3543434)

The Francis Crick Institute

Additional file 4: of Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy

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Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy

(A) Quantification of Akt or S6 protein expression in 17–25-week-old Myf5/Fktn LC and KO mice. Two-tailed Student’s t test. *p < 0.05. (B) Akt expression has a significant correlation with the proportion of ColVI+ area in KO muscle (Pearson r = 0.7922, p = 0.0337). n = 8 Myf5/Fktn LC and 8 Myf5/Fktn KO mice (n = 7 per group for ColVI analysis due to tissue artifacts). (PDF 325 kb

Additional file 1: of Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy

(A) Fold-change over background values for pro-inflammatory cytokines (IL-1Î˛, MCP-1, and TNF-Îą) tested via MILLIPLEX Map assay in quadriceps of daily RAPA study mice. (B) Fold-change over background values for TGF-Î˛ tested via MILLIPLEX Map assay in quadriceps muscle of daily RAPA study mice. (TIF 694 kb

Additional file 3: of Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy

(A) Distribution of muscle fiber minimum diameter from non-regenerated muscle fibers in iliopsoas of VEH- and RAPA-treated LC and KO mice. Fibers are grouped into bins of 2.5 μm. Two-way ANOVA performed for each bin. *, Drug*Genotype p < 0.05; †, Genotype p < 0.05. n = 5 VEH LC (tissue artifact), n = 5 RAPA LC (tissue artifact), n = 7 VEH KO, n = 7 RAPA KO. (B) Distribution of muscle fiber minimum cross-sectional diameter from regenerated muscle fibers in iliopsoas of VEH- and RAPA-treated KO mice. Fibers are grouped into bins of 2.5 μm. Regenerated fiber numbers range from 64 to 360 in VEH KO mice and 5–217 in RAPA KO mice. n = 7 VEH KO, n = 6 RAPA KO (mouse sample with only five regenerating fibers was excluded from fiber size bin analysis). Two-tailed Student’s t test; *p < 0.05. (PDF 276 kb

Additional file 2: of Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy

https://figshare.com/articles/Additional_file_3_of_Four-week_rapamycin_treatment_improves_muscular_dystrophy_in_a_fukutin-deficient_mouse_model_of_dystroglycanopathy/4430981

Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy

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The Francis Crick Institute

Springer - Publisher Connector

The Francis Crick Institute

Springer - Publisher Connector

The Francis Crick Institute

The Francis Crick Institute