A Hunfeld

D Segelcke

H Lübbert

M Kremser

Journal of Headache and Pain

PubMed

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The Journal of Headache and Pain

EHMTI-0092. Activation of the 5-HT2B receptor induces dural plasma protein extravasation in a mouse migraine model

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MEETING ABSTRACT Open Access
EHMTI-0092. Activation of the 5-HT2B receptor
induces dural plasma protein extravasation in a
mouse migraine model
A Hunfeld*, M Kremser, D Segelcke, H Lübbert
From 4th European Headache and Migraine Trust International Congress: EHMTIC 2014
Copenhagen, Denmark. 18-21 September 2014
Introduction
Migraine attacks originate in the meninges which are den-
sely innervated by trigeminal nerve fibers. Upon stimula-
tion, endothelial cells of dural blood vessels secrete nitric
oxide and as a consequence, neuropeptides are released
from trigeminal nerve fibers. This, in turn, leads to menin-
geal plasmaproteinextravasation (PPE) and vasodilation.
Inflammatory components such as PPE and vasodilation
serve as indicators for migraine attacks in animal models.
A guinea pig migraine model was described in which the
partial 5-HT2B/2C receptor agonist meta-Chlorphenylpi-
perazine (mCPP) is applied to induce PPE in the dura
mater. We have transferred this model to mice.
Aim
Characterize the role of the 5-HT2B in a mouse migraine
model.
Methods
Tissue accumulation of the tracer Evans Blue is measured
to quantify the extent of the PPE.
Results
Mice are only responsive to mCPP after several weeks of
hypoxia. The induction of PPE in hypoxic mice is blocked
by the specific 5-HT2B receptor antagonist BF-1.
Conclusion
The 5-HT2B receptors play a crucial role in the induction
of migraine symptoms in hypoxic mice.
No conflict of interest.
Published: 18 September 2014
doi:10.1186/1129-2377-15-S1-F11
Cite this article as: Hunfeld et al.: EHMTI-0092. Activation of the 5-HT2B
receptor induces dural plasma protein extravasation in a mouse
migraine model. The Journal of Headache and Pain 2014 15(Suppl 1):F11.
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Animal Physiology, Faculty of Biology and Biotechnology, Bochum, Germany
Hunfeld et al. The Journal of Headache and Pain 2014, 15(Suppl 1):F11
http://www.thejournalofheadacheandpain.com/content/15/S1/F11
© 2014 Hunfeld et al; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.


http://dx.doi.org/10.1186/1129-2377-15-S1-F11

EHMTI-0092. Activation of the 5-HT2B receptor induces dural plasma protein extravasation in a mouse migraine model

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