Keisuke Ota

Ryota Miyata

Toru Aonishi

BMC Neuroscience

English

PubMed

Springer - Publisher Connector

POSTER PRESENTATION Open Access
Optimal pair of hippocampal CA1 phase response
curve and spike-timing-dependent plasticity for
hetero-associative memory
Ryota Miyata1,2*, Keisuke Ota3, Toru Aonishi1
From Twenty Second Annual Computational Neuroscience Meeting: CNS*2013
Paris, France. 13-18 July 2013
Recently reported experimental findings suggest that the
hippocampal CA1 network stores spatio-temporal spike
patterns and retrieves temporally reversed [1] and
spread-out [2] patterns. In this paper, we explore the
idea that the properties of the neural interactions and
the synaptic plasticity rule in the CA1 network enable it
to function as a hetero-associative memory recalling
such reversed and spread-out spike patterns. In line
with Lengyel’s speculation [3], we derive optimally
designed spike-timing-dependent plasticity (STDP) rules
that are matched to neural interactions formalized in
terms of phase response curves (PRCs) for performing
the hetero-associative memory function (see Figure 1).
First, we formulate a hetero-associative memory network
recalling not only the normal spike patterns, but also
the reversed and doubly spread-out patterns as a phase
oscillator model consisting of an STDP and a PRC.
Next, we analytically derive the mutual information
between a stored phase pattern and a network output
for evaluating memory retrieval performance. By maxi-
mizing an object function given by the mutual informa-
tion, we search for STDP window functions that are
optimal for retrieval of normal and doubly spread-out
patterns under the constraint that the PRCs are those of
CA1 pyramidal neurons recorded in vitro [4].
Conclusions
The typical STDPs observed in CA1 region are classified
into two types [5]: symmetric and asymmetric plasticity
rules. We show both of these rules are included in the
* Correspondence: miyata@acs.dis.titech.ac.jp
1Interdisciplinary Graduate School of Science, Tokyo Institute of Technology,
Kanagawa, 226-8502, Japan
Full list of author information is available at the end of the article
Figure 1 Outline of our approach to derive pairs of PRCs and STDPs optimally recalling normal, reversed, and doubly spread-out
patterns.
Miyata et al. BMC Neuroscience 2013, 14(Suppl 1):P9
http://www.biomedcentral.com/1471-2202/14/S1/P9
© 2013 Miyata et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
theoretically derived set of optimal STDPs. The theoreti-
cally derived STDPs qualitatively coincide with the first
two Fourier series approximations for those reported in
CA1 neurons. Furthermore, we demonstrate that the sys-
tem, which can retrieve normal and doubly spread-out
patterns, can also retrieve reversed patterns with the same
quality.
Author details
1Interdisciplinary Graduate School of Science, Tokyo Institute of Technology,
Kanagawa, 226-8502, Japan. 2Research Fellow of the Japan Society for the
Promotion of Science, Tokyo, Japan. 3Brain Science Institute, RIKEN, Saitama,
351-0198, Japan.
Published: 8 July 2013
References
1. Foster DJ, Wilson MA: Reverse replay of behavioural sequences in
hipppocampal place cells during the awake state. Nature 2006,
440:680-683.
2. Louie K, Wilson MA: Temporally structured replay of awake hippocampal
ensemble activity during rapid eye movement sleep. Neuron 2001,
29:145-156.
3. Lengyel M, Kwag J, Paulsen O, Dayan P: Matching storage and recall:
Hippocampal spike timing-dependent plasticity and phase response
curves. Nature Neuroscience 2005, 8:1677-1683.
4. Ota K, Omori T, Watanabe S, Miyakawa H, Okada M, Aonishi T:
Measurement of infinitesimal phase response curves from noisy real
neurons. Physical Review E 2011, 84:041902.
5. Tsukada M, Aihara T, Kobayashi Y, Shimazaki H: Spatial analysis of spike-
timing-dependent LTP and LTD in the CA1 area of hippocampal slices
using optical imaging. Hippocampus 2005, 15:104-109.
doi:10.1186/1471-2202-14-S1-P9
Cite this article as: Miyata et al.: Optimal pair of hippocampal CA1
phase response curve and spike-timing-dependent plasticity for hetero-
associative memory. BMC Neuroscience 2013 14(Suppl 1):P9.
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Miyata et al. BMC Neuroscience 2013, 14(Suppl 1):P9
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Optimal pair of hippocampal CA1 phase response curve and spike-timing-dependent plasticity for hetero-associative memory

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Optimal pair of hippocampal CA1 phase response curve and spike-timing-dependent plasticity for hetero-associative memory

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