The mechanism of the hydrogenation of acetonitrile (CH3CN and CD3CN) to amines over a platinum filmand Pt/Al2O3 catalyst was investigated by in situ infrared spectroscopy. The reaction was studied under realisticconditions -liquid phase with toluene as solvent- using a flow-through cell-microreactor in attenuated total reflection(ATR) mode developed in our research group. Reaction intermediates were identified combining infrared spectra withtheoretical modeling by DFT. A sequential hydrogenation mechanism is proposed. Acetonitrile linearly and 2-foldchemisorbed on platinum sites is hydrogenated to form an imine surface intermediate (CH3CH=NH), which ishydrogenated to ethylamine. In turn, this imine intermediate can condense producing diethylamine and triethylamineand ammonia as a by-product. The time-evolution of the IR signals were modeled using a proposed microkineticmechanism and intrinsic kinetic constants were obtained under chemical control.Fil: Vogt, Lautaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Quaino, Paola Monica. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Calaza, Florencia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Collins, Sebastián Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina255th American Chemical Society National Meeting and ExpositionNew OrleansEstados UnidosAmerican Chemical Societ