Abdullah Baysan

Fevzi Demirel

Mustafa Gulec

Osman Sener

Ozgur Kartal

Sait Yesillik

Ugur Musabak

Clinical and Translational Allergy

PubMed

Springer - Publisher Connector

POSTER PRESENTATION Open Access
Multifocal fixed drug eruption due to ornidazole
Fevzi Demirel*, Abdullah Baysan, Sait Yesillik, Ozgur Kartal, Mustafa Gulec, Ugur Musabak, Osman Sener
From 6th Drug Hypersensitivity Meeting (DHM 6)
Bern, Switzerland. 9-12 April 2014
Introduction
Ornidazole, a synthetic nitroimidazole derivative, is
widely used in clinical practice. Ornidazol has low rate
of side effects, but sometimes may cause significant
allergic reactions such as fixed drug eruption (FDE). We
describe a case of multifocal FDE caused by ornidazole.
Case report
A 40-year old woman applied to the Immunology and
Allergy clinic with pruritic erythematous lesions over the
lateral sides of both arms and right hip within 30 minutes
after the ingestion of ornizadole 500 mg tablet. She
reported that five recurrent reactions emerged with the
same drug on the same locations previously, and their
severity was increased consecutively. She was prescribed
ornidazole for trichomonal vaginitis and she never
warned physicians about the previous drug reactions. In
view of the personal history and physical examination a
diagnosis of FDE due to ornidazole was diagnosed. After
a month from the last reaction allergy tests including
prick, intradermal and patch tests were performed with
ornidazole and metranidazole. Skin tests with 1/100 W/
vol and 1/10 W/vol concentrations and undiluted form
of the two drugs were negative. The patch tests consisted
of the same drug concentrations were applied to the
lesion site on her left arm. Readings were done at
48 hour later and positive results were obtained with
ornidazole but not with metranidazole. A placebo con-
trolled oral challenge was performed with metranidazole
and no reaction was observed. Following, she contunied
to receive metranidazole without any problem.
Conclusion
The lesionel patch test is more diagnostic than other
allergy tests at recürrent fixed drug reactions. The patch
test may be performed with the same drug solutions as
performed on skin prick and intradermal tests without
adding petrolatum. Although metronidazole and ornida-
zole are chemically related drugs, and metranidazole is
known more susceptible to cause FDE, metranidazole
may be an alternative drug to ornidazole like our case.
Published: 18 July 2014
doi:10.1186/2045-7022-4-S3-P99
Cite this article as: Demirel et al.: Multifocal fixed drug eruption due to
ornidazole. Clinical and Translational Allergy 2014 4(Suppl 3):P99.
Submit your next manuscript to BioMed Central
and take full advantage of: 
• Convenient online submission
• Thorough peer review
• No space constraints or color figure charges
• Immediate publication on acceptance
• Inclusion in PubMed, CAS, Scopus and Google Scholar
• Research which is freely available for redistribution
Submit your manuscript at 
www.biomedcentral.com/submitGulhane Military Medical Academy and Medical School, Division of
Immunology and Allergic Diseases, Turkey
Demirel et al. Clinical and Translational Allergy 2014, 4(Suppl 3):P99
http://www.ctajournal.com/content/4/S3/P99
© 2014 Demirel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://
creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.


Multifocal fixed drug eruption due to ornidazole

file:///data/core-remote/dit/data/Springer-OA/pdf/ac1/aHR0cDovL2xpbmsuc3ByaW5nZXIuY29tLzEwLjExODYvMjA0NS03MDIyLTQtUzMtUDk5LnBkZg==.pdf

Multifocal fixed drug eruption due to ornidazole

Abstract

Similar works

Full text

Available Versions

Springer - Publisher Connector