Magna Correia

João Freitas

Rita Vieira

Filipe Perneta

Luz Brazão

Clinical and Translational Allergy

Adverse reactions to drugs, Fixed Erythema (FE), correspond to 16-21% of all skin eruptions. This disease results in the development of one or more erythematous annular or oval, plaques as a result of systemic exposure to a drug. On reexposure relapse occurs in the same place, although new lesions may arise simultaneously in other areas. Any drug can cause FE. The physiopathology involves an allergic reaction (vasculitis).info:eu-repo/semantics/publishedVersio

Correia, Magna

Freitas, João

Vieira, Rita

Perneta, Filipe

Brazão, Luz

Repositório Comum

POSTER PRESENTATION Open AccessFluconazole - a case report on fixed drugeruptionMagna Correia1*, Magna Correia2, João Freitas2, Rita Vieira2, Filipe Perneta2, Luz Brazão2From 6th Drug Hypersensitivity Meeting (DHM 6)Bern, Switzerland. 9-12 April 2014BackgroundAdverse reactions to drugs, Fixed Erythema (FE), corre-spond to 16-21% of all skin eruptions. This diseaseresults in the development of one or more erythematousannular or oval, plaques as a result of systemic exposureto a drug. On reexposure relapse occurs in the sameplace, although new lesions may arise simultaneously inother areas. Any drug can cause FE. The physiopathologyinvolves an allergic reaction (vasculitis).Methods and materialAfter theoretical revision and the consultation of theclinical file, the authors present a clinical case of fixeddrug eruption to Fluconazole, pointing out the ana-mnesis, the examination and further complementaryexams of diagnosis.Case studyFemale patient of 43 years, with a past history of recur-rent vaginal candidiasis, treated every time with oral Flu-conazole that attended our emergency department withwell demarcated erythematous plaque located on theright side of the upper lip. The patient referred that thebeginning of the injuries occurred about 12 hours aftertaking 150 mg of fluconazole and mentioned no pain ouritchy sensation. Our initial assessment was simultaneousvaginal candidiasis and herpes simplex. As so Valaciclovirwas prescribed and the patient was discharged. Howeverafter the 4th day of treatment a new lesion similar to thefirst appeared on the dorsal part of her hand. On thisnew signal, the patient was diagnosed with fixed pigmen-ted erythema to fluconazole. She stopped Valaciclovirand Fluconazole and started a topical medium power cor-ticosteroid and a systemic antihistamine.ConclusionFE has a spontaneous recovery and no complicationswith drug withdrawal. The use of antihistamines andtopical corticosteroids relieve symptoms associated withthe disease.Authors’ details1Internal Medicine Department – Central Hospital of Funchal – Madeira,Portugal, Portugal. 2SESARAM, Internal Medicine, Portugal.Published: 18 July 2014doi:10.1186/2045-7022-4-S3-P72Cite this article as: Correia et al.: Fluconazole - a case report on fixeddrug eruption. Clinical and Translational Allergy 2014 4(Suppl 3):P72.Submit your next manuscript to BioMed Centraland take full advantage of: • Convenient online submission• Thorough peer review• No space constraints or color figure charges• Immediate publication on acceptance• Inclusion in PubMed, CAS, Scopus and Google Scholar• Research which is freely available for redistributionSubmit your manuscript at www.biomedcentral.com/submit1Internal Medicine Department – Central Hospital of Funchal – Madeira,Portugal, PortugalFull list of author information is available at the end of the articleCorreia et al. Clinical and Translational Allergy 2014, 4(Suppl 3):P72http://www.ctajournal.com/content/4/S3/P72© 2014 Correia et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative CommonsAttribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction inany medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Portuguese

Fluconazole - a case report on fixed drug eruption

Fluconazole - a case report on fixed drug eruption (Poster)

Springer - Publisher Connector

POSTER PRESENTATION Open Access
Fluconazole - a case report on fixed drug
eruption
Magna Correia1*, Magna Correia2, João Freitas2, Rita Vieira2, Filipe Perneta2, Luz Brazão2
From 6th Drug Hypersensitivity Meeting (DHM 6)
Bern, Switzerland. 9-12 April 2014
Background
Adverse reactions to drugs, Fixed Erythema (FE), corre-
spond to 16-21% of all skin eruptions. This disease
results in the development of one or more erythematous
annular or oval, plaques as a result of systemic exposure
to a drug. On reexposure relapse occurs in the same
place, although new lesions may arise simultaneously in
other areas. Any drug can cause FE. The physiopathology
involves an allergic reaction (vasculitis).
Methods and material
After theoretical revision and the consultation of the
clinical file, the authors present a clinical case of fixed
drug eruption to Fluconazole, pointing out the ana-
mnesis, the examination and further complementary
exams of diagnosis.
Case study
Female patient of 43 years, with a past history of recur-
rent vaginal candidiasis, treated every time with oral Flu-
conazole that attended our emergency department with
well demarcated erythematous plaque located on the
right side of the upper lip. The patient referred that the
beginning of the injuries occurred about 12 hours after
taking 150 mg of fluconazole and mentioned no pain our
itchy sensation. Our initial assessment was simultaneous
vaginal candidiasis and herpes simplex. As so Valaciclovir
was prescribed and the patient was discharged. However
after the 4th day of treatment a new lesion similar to the
first appeared on the dorsal part of her hand. On this
new signal, the patient was diagnosed with fixed pigmen-
ted erythema to fluconazole. She stopped Valaciclovir
and Fluconazole and started a topical medium power cor-
ticosteroid and a systemic antihistamine.
Conclusion
FE has a spontaneous recovery and no complications
with drug withdrawal. The use of antihistamines and
topical corticosteroids relieve symptoms associated with
the disease.
Authors’ details
1Internal Medicine Department – Central Hospital of Funchal – Madeira,
Portugal, Portugal. 2SESARAM, Internal Medicine, Portugal.
Published: 18 July 2014
doi:10.1186/2045-7022-4-S3-P72
Cite this article as: Correia et al.: Fluconazole - a case report on fixed
drug eruption. Clinical and Translational Allergy 2014 4(Suppl 3):P72.
Submit your next manuscript to BioMed Central
and take full advantage of: 
• Convenient online submission
• Thorough peer review
• No space constraints or color figure charges
• Immediate publication on acceptance
• Inclusion in PubMed, CAS, Scopus and Google Scholar
• Research which is freely available for redistribution
Submit your manuscript at 
www.biomedcentral.com/submit
1Internal Medicine Department – Central Hospital of Funchal – Madeira,
Portugal, Portugal
Full list of author information is available at the end of the article
Correia et al. Clinical and Translational Allergy 2014, 4(Suppl 3):P72
http://www.ctajournal.com/content/4/S3/P72
© 2014 Correia et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://
creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.


Crossref

Fluconazole ‐ a case report on fixed drug eruption

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Poster Presentation  6th Drug Hypersensitivity Meeting (DHM 6)

https://comum.rcaap.pt/bitstream/10400.26/32999/1/Fluconazole-A%20Case%20Report%20%20On%20Fixed%20drug%20eruption.pdf

Fluconazole - a case report on fixed drug eruption

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