A Johansson

E Nielsen

FC Kugelberg

H Sandler

J Ahlner

M Bertilsson

S Rubertsson

U Lennborn

Springer - Publisher Connector

POSTER PRESENTATION Open Access
Intox - a prospective measurement of blood
concentrations of routine drugs in patients
treated in the intensive care unit
U Lennborn1*, E Nielsen2, H Sandler3, M Bertilsson4, A Johansson5, J Ahlner5, FC Kugelberg5, S Rubertsson1
From ESICM LIVES 2015
Berlin, Germany. 3-7 October 2015
Introduction
Standard dosages and resulting range of blood concentra-
tions of analgesic and sedative drugs given to ICU patients,
with a varying degree of organ failure, may affect the
disposition (absorption, distribution, metabolism and
excretion) of the drugs administered. Drug metabolism in
ICU patients need to be further investigated.
Objectives
The aim of this project is to study the pharmacokinetics
of analgesic and sedative drugs in a cohort of a Swedish
general ICU with special focus on fentanyl and propofol.
Methods
A prospective, observational pilot study of 69 patients was
performed in the general ICU at Uppsala University hospi-
tal, Sweden. Blood samples were collected according to
routine procedures upon the patient’s arrival at the ICU,
and then twice daily. The blood samples were sent to the
National Board of Forensic Medicine in Linköping,
Sweden, for analysis of drug concentrations.
Results
Measured blood concentrations related to the total
24-hour dose for fentanyl is showed in Figure 1 and for
propofol in Figure 2.
Conclusions
The variety of drug concentrations observed in relation to
standard dosages of fentanyl and propofol, together with
other drugs, need to be further investigated in a larger
ICU population since this may affect the length of stay in
the ICU and in the end health economics.
1Uppsala University, Department of Surgical Sciences / Anaesthesiology and
Intensive Care Medicine, Uppsala, Sweden
Full list of author information is available at the end of the article
Figure 1 Fentanyl.
Figure 2 Propofol.
Lennborn et al. Intensive Care Medicine Experimental 2015, 3(Suppl 1):A496
http://www.icm-experimental.com/content/3/S1/A496
© 2015 Lennborn et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided
the original work is properly cited.
Authors’ details
1Uppsala University, Department of Surgical Sciences / Anaesthesiology and
Intensive Care Medicine, Uppsala, Sweden. 2Uppsala University, Department
of Pharmaceutical Biosciences, Uppsala, Sweden. 3Uppsala University,
Department of Surgical Sciences / Forensic Medicine, Uppsala, Sweden.
4Uppsala University, Uppsala Clinical Research Center, Uppsala, Sweden.
5National Board of Forensic Medicine, Department of Forensic Genetics and
Forensic Toxicology, Linköping, Sweden.
Published: 1 October 2015
doi:10.1186/2197-425X-3-S1-A496
Cite this article as: Lennborn et al.: Intox - a prospective
measurement of blood concentrations of routine drugs in patients
treated in the intensive care unit. Intensive Care Medicine Experimental
2015 3(Suppl 1):A496.
Submit your manuscript to a 
journal and benefi t from:
7 Convenient online submission
7 Rigorous peer review
7 Immediate publication on acceptance
7 Open access: articles freely available online
7 High visibility within the fi eld
7 Retaining the copyright to your article
    Submit your next manuscript at 7 springeropen.com
Lennborn et al. Intensive Care Medicine Experimental 2015, 3(Suppl 1):A496
http://www.icm-experimental.com/content/3/S1/A496
Page 2 of 2


INTOX - A PROSPECTIVE MEASUREMENT OF BLOOD CONCENTRATIONS OF ROUTINE DRUGS IN PATIENTS TREATED IN THE INTENSIVE CARE UNIT

file:///data/core-remote/dit/data/Springer-OA/pdf/ed7/aHR0cDovL2xpbmsuc3ByaW5nZXIuY29tLzEwLjExODYvMjE5Ny00MjVYLTMtUzEtQTQ5Ni5wZGY=.pdf

INTOX - A PROSPECTIVE MEASUREMENT OF BLOOD CONCENTRATIONS OF ROUTINE DRUGS IN PATIENTS TREATED IN THE INTENSIVE CARE UNIT

Abstract

Similar works

Full text

Available Versions

Springer - Publisher Connector