H Brunner

Pediatric Rheumatology

PubMed

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INVITED SPEAKER PRESENTATION Open Access
PReS13-SPK-1028: Activity and damage - we have to
measure them
H Brunner
From 20th Pediatric Rheumatology European Society (PReS) Congress
Ljubljana, Slovenia. 25-29 September 2013
Background
Childhood-onset SLE is a complex multiorgan disease.
In order to judge the need of medical intervnetions and
the patient benefits from them, measurement disease
activity and damage are key. Furthermore, important
improvement and deterioration of disease needs to be
ascertained. Such measurement are the basis for clinical
trial aimed at identifying improved medications and are
needed to judge the benefits of medical interventions in
general.
Methods
An overview will be provided about current surrogate
and biological markers of global and disease specific dis-
ease activity and damage. Focus will be placed on the
relevance for children with SLE and current research
activities, particularly NPSLE and lupus nephritis.
Results & deliverables
Upon completion of the presentation the audience will h
ave a firm understanding about the suitability of indivi-
dual measures of disease activity and their differences.
Measures include the various versions of the SLEDAI
and BILAG, as well as SLE flare tools. The SLICC
Damage Index and its pediatric version will be discussed
in addition to previously validated measures of clinically
relevant improvment and disease flare. Additionally, bio-
markers of lupus nephritis as they are suited to help diag-
nose kidney disease and anticipate changes in the activity
and chronicity of kidney lesions will be available. Some
novel imaging biomarkers of neuropsychiatric damage
will be reviewed.
Disclosure of interest
None declared.
Published: 5 December 2013
doi:10.1186/1546-0096-11-S2-I22
Cite this article as: Brunner: PReS13-SPK-1028: Activity and damage - we
have to measure them. Pediatric Rheumatology 2013 11(Suppl 2):I22.
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Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA
Brunner Pediatric Rheumatology 2013, 11(Suppl 2):I22
http://www.ped-rheum.com/content/11/S2/I22
© 2013 Brunner; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction
in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.


PReS13-SPK-1028: Activity and damage - we have to measure them

http://dx.doi.org/10.1186/1546-0096-11-S2-I22

PReS13-SPK-1028: Activity and damage - we have to measure them

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