Genes that showed greater than four-fold upregulation in IBD. (XLSX 28 kb

Alfa Hc Bai

Huiling Wang

Ji-Fan Hu

Jun Yu

Kang Chao

Manying Li

Minhu Chen

Qiao Yu

Shenghong Zhang

Siew Chien Ng

Yi Cui

Genome Biology

PubMed

Genes that showed greater than four-fold downregulation in IBD. (XLSX 14 kb

Huiling Wang (169598)

Kang Chao (3471287)

Siew Ng (3523106)

Alfa Bai (3523109)

Qiao Yu (459097)

Jun Yu (5904)

Manying Li (738963)

Yi Cui (128888)

Minhu Chen (554703)

Ji-Fan Hu (130349)

Shenghong Zhang (554704)

The Francis Crick Institute

Additional file 2: Table S2. of Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

MiR-223 antagomirs therapy by direct intracolonic delivery. A Recovery of body weight in mice with colitis by miR-223 antagomirs. Control: colitis mice treated with ethanol; TNBS + Anti-miR: colitis mice treated with antagomir223; TNBS + Anti-CTL: colitis mice treated with an isotype control of antagomir223. B MiR-223 antagomirs therapy reduces the histological score. C Serum FITC-dextran was quantified as a measure of intestinal permeability. D Effects on MPO activity by miR-223 antagomirs. E MiR-223 antagomirs upregulate CLDN8 as quantitated by qPCR. F MiR-223 antagomirs upregulate CLDN8 as quantitated by western blot. G MiR-223 antagomirs downregulate miR-223. *P <0.05, **P <0.01, ***P <0.001. (EPS 5350 kb

Additional file 6: Figure S4. of Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

Crossref

Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

Abundance of miR-223 in the mimic- and inhibitor-treated cells. A MiR-223 mimics upregulate miR-223 in colonic epithelial cells by qPCR. B MiR-223 inhibitors downregulate miR-223 in colonic epithelial cells by qPCR. C MiR-223-positive cells in colonic mucosa of IBD patients by FISH. *P <0.05, **P <0.01, ***P <0.001. (EPS 1921 kb

Additional file 4: Figure S2. of Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

Additional file 1: Table S1. of Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

Springer - Publisher Connector

Identification of CLDN8 as a novel target controlled by the IL23 pathway in IBD. A Heatmap of IBD-associated mRNAs. Lanes 4A-6A:CD tissues; lanes 4B-6B: normal colons. B Western blot of CLDN8 in colonic inflamed mucosa of IBD patients. C Western blot of CLDN8 in colonic inflamed mucosa of colitis mice. D Anti-IL23P19 restored CLDN8 by western blot. (EPS 2313 kb

Additional file 3: Figure S1. of Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

https://figshare.com/articles/Additional_file_6_Figure_S4_of_Pro-inflammatory_miR-223_mediates_the_cross-talk_between_the_IL23_pathway_and_the_intestinal_barrier_in_inflammatory_bowel_disease/4414226

Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

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The Francis Crick Institute

The Francis Crick Institute

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The Francis Crick Institute

The Francis Crick Institute

Springer - Publisher Connector

The Francis Crick Institute

Springer - Publisher Connector