Impact of a maternal immunization program against pertussis in a developing country

Abstract

Background: Pertussis disease is a growing concern for developing countries. In Argentina, rates of illness and death peaked in 2011. More than 50% of fatalities due to pertussis occurred in infants younger than two months of age, too young for vaccination. In 2012, the government offered immunization with a vaccine containing Tdap to all pregnant women after 20 weeks of gestation with the intent of reducing morbidity and mortality in young infants. Methods: Maternal acellular pertussis vaccine impact on reducing infant disease burden was estimated based on data from the Argentinean Health Surveillance System. We divided Argentinean states in two groups experiencing high (>50) and low (⩽50) Tdap vaccine coverage and compared these two groups using a Bayesian structural time-series model. Low coverage regions were used as a control group, and the time series were compared before and after the implementation of the Tdap program. Findings: We observed a relative reduction of 51% (95% CI [−67%, −35%]; p = 0.001) in pertussis cases in high coverage states in comparison with the low coverage areas. Analysis of infants between two and six months showed a 44% (95% CI [−66%, −24%]; p = 0.001) reduction in illness. Number of deaths was highest in 2011 with 76 fatalities, for an incidence rate of 2.9 per 100,000. Comparing with 2011, rates decreased by 87% to 10 subjects, or 0.9 per 100,000 in 2013. Interpretation: We show an age-dependent protective effect of maternal Tdap immunization in a developing country for infants younger than six months.Fil: Vizzotti, Carla. Ministerio de Salud de la Nación; ArgentinaFil: Juarez, Maria V.. Ministerio de Salud de la Nación; ArgentinaFil: Bergel, Eduardo. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Romanin, Viviana. Ministerio de Salud de la Nación; ArgentinaFil: Califano, Gloria. Ministerio de Salud de la Nación; ArgentinaFil: Sagradini, Sandra. Ministerio de Salud de la Nación; ArgentinaFil: Rancaño, Carolina. Ministerio de Salud de la Nación; ArgentinaFil: Aquino, Analía. Ministerio de Salud de la Nación; ArgentinaFil: Libster, Romina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina. Vanderbilt University; Estados UnidosFil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina. Vanderbilt University; Estados UnidosFil: Manzur, Juan. Ministerio de Salud de la Nación; Argentin