Vonk Noordegraaf, A. [Promotor]Bogaard, H.J. [Copromotor

de Raaf, M.A.

English

NARCIS 

Targeting the cause, affecting the course: Characterization and Optimization of Experimental Models for Pulmonary Arterial Hypertension

Raaf, M.A. de

DSpace at VU

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Targeting the Cause, affecting the Course: Characterization and Optimization of Experimental Models for Pulmonary Arterial Hypertension

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VU Research PortalTargeting the Cause, affecting the Coursede Raaf, M.A.2016document versionPublisher's PDF, also known as Version of recordLink to publication in VU Research Portalcitation for published version (APA)de Raaf, M. A. (2016). Targeting the Cause, affecting the Course: Characterization and Optimization ofExperimental Models for Pulmonary Arterial Hypertension.General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            • Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            • You may not further distribute the material or use it for any profit-making activity or commercial gain            • You may freely distribute the URL identifying the publication in the public portal ?Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.E-mail address:vuresearchportal.ub@vu.nlDownload date: 27. May. 2021Targeting the causea"ecting the courseCharacterization and Optimization of Experimental Models for Pulmonary Arterial HypertensionMichiel Alexander de RaafTargeting the cause a"ecting the course            M.A. De RaafCharacterization and Optimization of Experimental Models for Pulmonary Arterial HypertensionPulmonary Arterial Hypertension is a progressive and devastating disease char-acterized by dysfunction and remodeling of the pulmonary vasculature, lead-ing to increased pulmonary vascular resistance, compensatory right ventricu-lar remodeling and eventually dilatation and heart failure. To find an e"ective treatment for Pulmonary Arterial Hypertension, animal models are used to simulate the disease.In this thesis, Michiel Alexander de Raaf and colleagues describe and character-ize the disease progression of such animal model; the Sugen Hypoxia model. Several treatments were tested and evaluated on their e#cacy. As both lungs and heart use mutual pathways for disease progression as well as for compen-satory remodeling against the disease, the treatment paradox ‘what might be beneficial for the lungs, could harm the right ventricle’ was evaluated.

Targeting the Cause, affecting the Course:Characterization and Optimization of Experimental Models for Pulmonary Arterial Hypertension

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