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Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis

Abstract

Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed by the local vascular endothelia. alpha4 Integrins and their receptors play an important role during homing of cells to the inflammatory site. In the present study, the effect of alpha4-integrin inhibitor on the development of EAU was investigated.Fil: Martín, Andrea P.. Universidade de Sao Paulo; BrasilFil: Vieira de Moraes, Luciana. Universidade de Sao Paulo; BrasilFil: Tadokoro, Carlos E.. Universidade de Sao Paulo; BrasilFil: Commodaro, Alessandra G.. Universidade de Sao Paulo; BrasilFil: Urrets Zavalia, Enrique. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Urrets Zavalía, Julio Alberto. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Rizzo, Luiz V.. Universidade de Sao Paulo; Brasil. Fundação Zerbini; BrasilFil: Serra, Horacio Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentin

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