Cynthia K Rigsby

Joshua D Robinson

Keyur Parekh

Michael Markl

Patrick Magrath

Journal of Cardiovascular Magnetic Resonance

PubMed

Springer - Publisher Connector

POSTER PRESENTATION Open Access
Assessment of myocardial motion in children and
young adults using High-temporal resolution MR
tissue phase mapping
Keyur Parekh*, Michael Markl, Patrick Magrath, Joshua D Robinson, Cynthia K Rigsby
From 17th Annual SCMR Scientific Sessions
New Orleans, LA, USA. 16-19 January 2014
Background
MR Tissue phase mapping (TPM) is a non-invasive tool
to detect regional and global myocardial wall motion.
Evaluation of myocardial velocity in radial and longitudi-
nal direction throughout the cardiac cycle may help us
better understand myocardial mechanics. Our goal is to
investigate regional and global left ventricular myocar-
dial motion using respiratory-gated high temporal reso-
lution TPM in children and young adults.
Methods
The HIPAA compliant prospective study was IRB
approved. Twelve patients (mean age 14.8 years; range
5-22 years) underwent cardiac magnetic resonance
(CMR) (1.5-T) including TPM (spatial resolution of 2.2
× 3.0 mm and temporal resolution of 20.4 ms). Nine
patients with no intrinsic myocardial abnormality based
on clinical history, standard biomarkers, MRI and echo-
cardiographic data were compared with 2 patients hav-
ing cardiac dysfunction and 1 patient with hypertrophic
cardiomyopathy (HCM). Short axis images at base, mid-
chamber and apex were manually contoured to outline
the epicardium and endocardium. Data was post-pro-
cessed using software programmed in Matlab (The
Mathworks Inc., Natick, MA, USA) to obtain segmental
radial and longitudinal velocities of left ventricle.
Northwestern University, Chicago, Illinois, USA
Figure 1 Elevated systolic longitudinal velocity in hypertrophic cardiomyopathy (HCM) denotes hyperdynamic function and reduced
velocity in patient with dilated cardiomyopathy (DCM) indicates systolic dysfunction. Diastolic dysfunction in patients with HCM and DCM
is demonstrated by reduced diastolic longitudinal velocities. Delayed relaxation of left ventricle in patient with DCM is noted.
Parekh et al. Journal of Cardiovascular Magnetic
Resonance 2014, 16(Suppl 1):P328
http://www.jcmr-online.com/content/16/S1/P328
© 2014 Parekh et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://
creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Results
Regional and global assessment of radial (contraction and
relaxation) and longitudinal (lengthening and shortening)
myocardial motion could be detected. Peak radial and
longitudinal velocity in systole and diastole were different
in our age group compared to documented velocities in
adults. Average peak longitudinal velocity in systole in
HCM was 5.79 ± 1.82 cm/s (compared to 4.01 ± 2.33 cm/s
in normals) implies hyperdynamic function in HCM.
Average peak radial velocity in systole in patients with and
without cardiac dysfunction was 2.71 ± 1.48 cm/s and
3.52 ± 1.81 cm/s respectively. Reduced velocities in patients
with cardiac dysfunction indicate poor systolic function.
Reduced average peak radial velocity in diastole in HCM
(-3.82 ± 1.37 cm/s) compared to normal population
(-5.93 ± 2.48 cm/s) denotes impaired relaxation of left ven-
tricle and diastolic dysfunction in HCM.
Conclusions
Velocity-mapping technique quantifies regional and glo-
bal systolic and diastolic myocardial motion. Our preli-
minary result demonstrates a role for TPM to determine
systolic and diastolic dysfunction in our age group.
Myocardial velocities in children and young adults were
different from documented velocities in adults. Recruit-
ment is underway to validate our results in larger
cohort.
Funding
None.
Published: 16 January 2014
doi:10.1186/1532-429X-16-S1-P328
Cite this article as: Parekh et al.: Assessment of myocardial motion in
children and young adults using High-temporal resolution MR tissue
phase mapping. Journal of Cardiovascular Magnetic Resonance 2014
16(Suppl 1):P328.
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Figure 2 Reduced time to peak during systole in hypertrophic cardiomyopathy (HCM) and sluggish peak with low velocities in patient
with dilated cardiomyopathy (DCM) noted. Impaired relaxation of left ventricle seen in both HCM and DCM patient.
Parekh et al. Journal of Cardiovascular Magnetic
Resonance 2014, 16(Suppl 1):P328
http://www.jcmr-online.com/content/16/S1/P328
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Assessment of myocardial motion in children and young adults using High-temporal resolution MR tissue phase mapping

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Assessment of myocardial motion in children and young adults using High-temporal resolution MR tissue phase mapping

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