José Canosa

Mary Zamora

Mayda León

Maytee Morejó

Mercedes Díaz

Mirta Castello

Raúl Almarales

World Allergy Organization Journal

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MEETING ABSTRACT Open Access
Immunotherapy – 2074. Tolerability of sublingual
immunotherapy with tropical mite allergen
vaccines using different dosing schedules in
asthmatic children
Raúl Lázaro Castro Almarales1*, Mirta Alvarez Castello2, José Severino Rodríguez Canosa3,
Mercedes Ronquillo Díaz4, Mayda González León5, Mary Carmen Reyes Zamora6, Maytee Mateo Morejó6
From 2nd WAO International Scientific Conference (WISC 2012)
Hyderabad, India. 6-9 December 2012
Background
Immunotherapy with mite allergens is effective both in
rhinitis and asthma. However, injection immunotherapy
carries a high risk of systemic adverse events, so, the
sublingual route (SLIT) is being used more frequently.
Efficacy of SLIT in asthma has been widely studied,
however, in Cuba, the therapeutic effect of mite vaccines
of Dermatophagoides pteronyssinus (Dp), D.siboney (Ds)
and Blomia tropicalis(Bt) has been demonstrated only in
adults, but not children. This aim is to determinate
adherence and tolerability of SLIT with mite allergen
vaccines using different treatment schedules in asth-
matic children.
Methods
One hundred and twenty children (2 to 15 years) with
mild to moderate asthma were selected for each treatment
schedule. Three dosing schedules were used: (1) maximum
of 3 daily drops; (2): max. 5 drops and (3) max. 10 drops,
all by sublingual route. Incremental updosing was used for
3 weeks. A maintenance dose of 2000 BU was used once a
week for schedule 1 and twice a week for schedules 2 and
3, during 2 months. Standardized House Dust Mite allergen
vaccines of Dermatophagoides pteronyssinus, D. siboney and
Blomia tropicaliswere employed (VALERGEN, BIOCEN,
Cuba).
Results
Adherence to treatment was above 90% for the three
schemes with no statistically significant difference
(p>0,08) among them. The patients tolerated the differ-
ent dosing schedules without having to change the
planned scheme. Only two patients reported local
adverse reactions, classified both as grade I (mild tongue
itching without medication).
Conclusions
Summarizing, all children tolerated the three schedules
similarly and adherence was high.
Author details
1Allergens Department, National Center of Bioproducts (BIOCEN), Allergology
and General Integral Medicine, La Habana, Cuba. 2Allergology Department,
University Hospital General Calixto García, Havana, Cuba; WAO Member;
Cuban Society of Allergy, Asthma and Clinical Immunology, Member; Cuban
Society of Immunology Member. 3Allergen Service, University Hospital
“General Calixto García”, Havana, Cuba; WAO Member; Cuban Society of
Allergy, Asthma and Clinical Immunology, Member; Cuban Society of
Immunology Member. 4Allergen Service, University Hospital “General Calixto
García”, Havana, Cuba. 5Docent Polyclinic “Pedro Fonseca”, Havana, Cuba
Cuban Society of Integral General Medicine, Member; Cuban Society of
Allergy, Asthma and Clinical Immunology, Member; Cuban Society of
Immunology Member. 6Allergen, Biocen, Cuba.
Published: 23 April 2013
doi:10.1186/1939-4551-6-S1-P156
Cite this article as: Almarales et al.: Immunotherapy – 2074. Tolerability
of sublingual immunotherapy with tropical mite allergen vaccines using
different dosing schedules in asthmatic children. World Allergy
Organization Journal 2013 6(Suppl 1):P156.
1Allergens Department, National Center of Bioproducts (BIOCEN), Allergology
and General Integral Medicine, La Habana, Cuba
Full list of author information is available at the end of the article
Almarales et al. World Allergy Organization Journal 2013, 6(Suppl 1):P156
http://www.waojournal.org/content/6/S1/P156
© 2013 Almarales et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited.


Immunotherapy – 2074. Tolerability of sublingual immunotherapy with tropical mite allergen vaccines using different dosing schedules in asthmatic children

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Immunotherapy – 2074. Tolerability of sublingual immunotherapy with tropical mite allergen vaccines using different dosing schedules in asthmatic children

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