Addison, Jennifer

Alcorn, David

Boyers, Dwayne

Brittenden, Julie

Campbell, Marion K

Cook, Jonathan

Cotton, Seonaidh C

Cuthbertson, Brian H

Elders, Andrew

Grant, Adrian

Hernández, Rodolfo

Kinsella, John

Norrie, John

Rae, Daniela

Stott, Stephen A

The FOCCUS study group

English

PubMed

Brian H Cuthbertson

Marion K Campbell

Stephen A Stott

Andrew Elders

Rodolfo Hernández

Dwayne Boyers

John Norrie

John Kinsella

Julie Brittenden

Jonathan Cook

Daniela Rae

Seonaidh C Cotton

David Alcorn

Jennifer Addison

Adrian Grant

null null

Springer - Publisher Connector

A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery - the FOCCUS study

Introduction: Fluid strategies may impact on patient outcomes in major elective surgery. We aimed to study the effectiveness and cost-effectiveness of pre-operative fluid loading in high-risk surgical patients undergoing major elective surgery.

Methods: This was a pragmatic, non-blinded, multi-centre, randomised, controlled trial. We sought to recruit 128 consecutive high-risk surgical patients undergoing major abdominal surgery. The patients underwent pre-operative fluid loading with 25 ml/kg of Ringer’s solution in the six hours before surgery. The control group had no preoperative fluid loading. The primary outcome was the number of hospital days after surgery with cost-effectiveness as a secondary outcome.

Results: A total of 111 patients were recruited within the study time frame in agreement with the funder. The median pre-operative fluid loading volume was 1,875 ml (IQR 1,375 to 2,025) in the fluid group compared to 0 (IQR 0 to 0) in controls with days in hospital after surgery 12.2 (SD 11.5) days compared to 17.4 (SD 20.0) and an adjusted mean difference of 5.5 days (median 2.2 days; 95% CI -0.44 to 11.44; P = 0.07). There was a reduction in adverse events in the fluid intervention group (P = 0.048) and no increase in fluid based

complications. The intervention was less costly and more effective (adjusted average cost saving: £2,047; adjusted average gain in benefit: 0.0431 quality adjusted life year (QALY)) and has a high probability of being cost-effective.

Conclusions: Pre-operative intravenous fluid loading leads to a non-significant reduction in hospital length of stay after high-risk major surgery and is likely to be cost-effective. Confirmatory work is required to determine whether these effects are reproducible, and to confirm whether this simple intervention could allow more cost-effective delivery of care

Cuthbertson, Brian H.

Campbell, Marion K.

Stott, Stephen A.

Cotton, Seonaidh C.

Enlighten: Publications

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A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery : the FOCCUS study

Cuthbertson, BH

Campbell, MK

Stott, SA

Elders, A

Hernández, R

Boyers, D

Norrie, J

Kinsella, J

Brittenden, J

Cook, J

Rae, D

Cotton, SC

Alcorn, D

Addison, J

Grant, A

Oxford University Research Archive

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A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery - the FOCCUS study

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