Institute for Medical Research and Occupational Health
Abstract
Ispitana je koncentracija koproporfirina, uroporfirina i porfobilinogena u 300 radnika profesionalno izloženih olovu. Usporedno su izvršene iste analize u 100 radnika kroničnih alkoholičara. Rezultati su uspoređeni s nalazima kontrolne skupine što ju je sačinjavala 50 radnika koji nisu bili izloženi olovu i 50 radnika koji nisu uživali alkohol. Utvrđeno je povećana izlučivanje koproporfirina i uroporfirina u radnika izloženih olovu, dok je povećano izlučivanje porfobilinogena nađeno samo u nekoliko ispitanika. Uroporfirini su redovito bili povećani kod većih ekspozicija olovu, kada je i izlučivanje olova urinom značajno povišeno. Ti rezultati potvrđuju da su koproporfirini u urinu značajan laboratorijski test pri ekspoziciji olovu. U radnika kroničnih alkoholičara, pored povećanog izlučivanja uroporfirina i koproporfirina, značajno je i povećano izlučivanje porfobilinogena.The concentrations of coproporphyrins, uroporphyrins and porphobilinogen were determined in 300 workers occupationally exposed to lead. The same analyses were done in 100 workers who were chronic alcoholics. The results were compared with those obtained in a control group which consisted of 50 nonexposed and 50 nondrinking workers. In lead exposed workers the excretion of coproporphyrins and uroporphyrins was increased. The increased excretion of porphobilinogen was found only in a few subjects. As a rule, uroporphyrins were elevated in cases of higher lead exposure, when urinary excretion of lead was also significantly increased. These data confirm that the determination of coproporphyrins in the urine is a significant labo-ratory test for the evaluation of lead exposure. In chronic alcoholics beside the increased excretion of uroporphyrins and coproporphyrins the elevated excretion of porphobilinogen is also important
