Institute for Medical Research and Occupational Health
Abstract
Single or repeated administration of Δ 9-tetrahydrocannabinol (30 mg/kg i.p.) increased 5-hydroxytryptamine levels in rats\u27 brain, but did not affect dopamine or noradrenaline levels. Brain and blood tryptophan levels were raised only after a single¬-dose regimen. The primary effect of Δ 9-tetrahydrocannabinol may be a mobilization of blood tryptophan by displacement from its albumin-bound depots, due to a high affinity of the drug for plasma albumin.Δ 9-tetrahidrokanabinol, apliciran jednokratno i višekratno (30 mg/kg, ip.) povećava nivo moždanog 5-hidroksitriptamina u štakora, ali ne i nivoe dopamina i noradrenalina. Nivo triptofana u mozgu i krvi povećava se samo nakon jednokratnog davanja. Primarni efekat Δ 9-tetrahidrokanabinola može da bude mobilizacija krvnog triptofana vezanog za albumin, što je posljedica velikog afiniteta Δ 9-tetrahidrokanabinola prema albuminu plazme
