Background. Oseltamivir resistance in A(H1N1)pdm09 influenza is rare, particularly in untreated community cases. Sustained community transmission has not previously been reported

A. C. Hurt

A. Kelso

A. Levy

Abed

B. Wang

Bloom

C. Dalton

Campbell

Chen

Creanga

D. Durrheim

D. E. Dwyer

D. W. Smith

Deng

Farias

Graitcer

Gubareva

Herlocher

Hurt

I. G. Barr

Ives

K. Hardie

Katoh

Kawai

Khandaker

L. Xue

Lackenby

Ling

M. Osbourn

Matsuzaki

Meijer

Memoli

Moore

N. Caldwell

N. Gehrig

N. J. Wilson

Newsome

P. Iannello

P. Wark

R. Booy

R. C. Givney

R. Dixit

R. Shaw

R. T. C. Lee

S. K. Leang

S. Maurer-Stroh

Saito

Sheu

Storms

T. Merritt

WHO Global fluenza Surveillance and Response System

WHO Global Influenza Surveillance Network

Wolfe

Y. M. Deng

English

PubMed

BACKGROUND: Oseltamivir resistance in A(H1N1)pdm09 influenza is rare, particularly in untreated community cases. Sustained community transmission has not previously been reported. METHODS: Influenza specimens from the Asia-Pacific region were collected through sentinel surveillance, hospital, and general practitioner networks. Clinical and epidemiological information was collected on patients infected with oseltamivir-resistant viruses. RESULTS: Twenty-nine (15%) of 191 A(H1N1)pdm09 viruses collected between May and September 2011 from Hunter New England (HNE), Australia, contained the H275Y neuraminidase substitution responsible for oseltamivir resistance. Only 1 patient had received oseltamivir before specimen collection. The resistant strains were genetically very closely related, suggesting the spread of a single variant. Ninety percent of cases lived within 50 kilometers. Three genetically similar oseltamivir-resistant variants were detected outside of HNE, including 1 strain from Perth, approximately 4000 kilometers away. Computational analysis predicted that neuraminidase substitutions V241I, N369K, and N386S in these viruses may offset the destabilizing effect of the H275Y substitution. CONCLUSIONS: This cluster represents the first widespread community transmission of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza. These cases and data on potential permissive mutations suggest that currently circulating A(H1N1)pdm09 viruses retain viral fitness in the presence of the H275Y mutation and that widespread emergence of oseltamivir-resistant strains may now be more likely

Hurt, AC

Hardie, K

Wilson, NJ

Deng, YM

Osbourn, M

Leang, SK

Lee, RTC

Iannello, P

Gehrig, N

Shaw, R

Wark, P

Caldwell, N

Givney, RC

Xue, L

Maurer-Stroh, S

Dwyer, DE

Wang, B

Smith, DW

Levy, A

Booy, R

Dixit, R

Merritt, T

Kelso, A

Dalton, C

Durrheim, D

Barr, IG

University of Melbourne Institutional Repository

The Journal of Infectious Diseases

Characteristics of a Widespread Community Cluster of H275Y Oseltamivir-Resistant A (H1N1)pdm09 Influenza in Australia

Background. Oseltamivir resistance in A(H1N1)pdm09 influenza is rare, particularly in untreated community cases. Sustained community transmission has not previously been reported.Methods.Influenza specimens from the Asia-Pacific region were collected through sentinel surveillance, hospital, and general practitioner networks. Clinical and epidemiological information was collected on patients infected with oseltamivir-resistant viruses.Results.Twenty-nine (15%) of 191 A(H1N1)pdm09 viruses collected between May and September 2011 from Hunter New England (HNE), Australia, contained the H275Y neuraminidase substitution responsible for oseltamivir resistance. Only 1 patient had received oseltamivir before specimen collection. The resistant strains were genetically very closely related, suggesting the spread of a single variant. Ninety percent of cases lived within 50 kilometers. Three genetically similar oseltamivir-resistant variants were detected outside of HNE, including 1 strain from Perth, approximately 4000 kilometers away. Computational analysis predicted that neuraminidase substitutions V241I, N369K, and N386S in these viruses may offset the destabilizing effect of the H275Y substitution.ConclusionsThis cluster represents the first widespread community transmission of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza. These cases and data on potential permissive mutations suggest that currently circulating A(H1N1)pdm09 viruses retain viral fitness in the presence of the H275Y mutation and that widespread emergence of oseltamivir-resistant strains may now be more likely.Published Versio

Hurt, A. C.

Hardie, K.

Wilson, N. J.

Osbourn, M.

Leang, S. K.

Lee, R. T. C.

Iannello, P.

Gehrig, N.

Shaw, R.

Wark, P.

Dwyer, D. E.

Wang, B.

Smith, D. W.

Levy, A.

Booy, R.

Dixit, R.

Merritt, T.

Kelso, A.

Givney, R. C.

Xue, L.

Dalton, C.

Durrheim, D.

Barr, I. G.

Deng, Yi-Mo

Caldwell, Natalie

Maurer-Stroh, Sebastian

Digital Repository - Nanyang Technological University

Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia

DR-NTU (Digital Repository of NTU)

Crossref

Characteristics of a Widespread Community Cluster of H275Y Oseltamivir-Resistant A(H1N1)pdm09 Influenza in Australia

Background: Oseltamivir resistance in A(H1N1)pdm09 influenza is rare, particularly in untreated community cases. Sustained community transmission has not previously been reported. Methods: Influenza specimens from the Asia–Pacific region were collected through sentinel surveillance, hospital, and general practitioner networks. Clinical and epidemiological information was collected on patients infected with oseltamivir-resistant viruses. Results: Twenty-nine (15%) of 191 A(H1N1)pdm09 viruses collected between May and September 2011 from Hunter New England (HNE), Australia, contained the H275Y neuraminidase substitution responsible for oseltamivir resistance. Only 1 patient had received oseltamivir before specimen collection. The resistant strains were genetically very closely related, suggesting the spread of a single variant. Ninety percent of cases lived within 50 kilometers. Three genetically similar oseltamivir-resistant variants were detected outside of HNE, including 1 strain from Perth, approximately 4000 kilometers away. Computational analysis predicted that neuraminidase substitutions V241I, N369K, and N386S in these viruses may offset the destabilizing effect of the H275Y substitution. Conclusions: This cluster represents the first widespread community transmission of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza. These cases and data on potential permissive mutations suggest that currently circulating A(H1N1)pdm09 viruses retain viral fitness in the presence of the H275Y mutation and that widespread emergence of oseltamivir-resistant strains may now be more likely

Caldwell, N.

Maurer-Stroh, S.

Dalton, C. B.

Durrheim, D. N.

Deng, Y. M.

University of Newcastle's Digital Repository

Characteristics of a widespread community cluster of H275Y Oseltamivir-Resistant A (H1N1)pdm09 influenza in Australia

Electronically published 4 May 2012.Background: Oseltamivir resistance in A(H1N1)pdm09 influenza is rare, particularly in untreated community cases. Sustained community transmission has not previously been reported. Methods: Influenza specimens from the Asia-Pacific region were collected through sentinel surveillance, hospital, and general practitioner networks. Clinical and epidemiological information was collected on patients infected with oseltamivir-resistant viruses. Results: Twenty-nine (15%) of 191 A(H1N1)pdm09 viruses collected between May and September 2011 from Hunter New England (HNE), Australia, contained the H275Y neuraminidase substitution responsible for oseltamivir resistance. Only 1 patient had received oseltamivir before specimen collection. The resistant strains were genetically very closely related, suggesting the spread of a single variant. Ninety percent of cases lived within 50 kilometers. Three genetically similar oseltamivir-resistant variants were detected outside of HNE, including 1 strain from Perth, approximately 4000 kilometers away. Computational analysis predicted that neuraminidase substitutions V241I, N369K, and N386S in these viruses may offset the destabilizing effect of the H275Y substitution. Conclusions: This cluster represents the first widespread community transmission of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza. These cases and data on potential permissive mutations suggest that currently circulating A(H1N1)pdm09 viruses retain viral fitness in the presence of the H275Y mutation and that widespread emergence of oseltamivir-resistant strains may now be more likely.A. C. Hurt, K. Hardie, N. J. Wilson, Y. M. Deng, M. Osbourn, S. K. Leang, R. T. C. Lee, P. Iannello, N. Gehrig, R. Shaw, P. Wark, N. Caldwell, R. C. Givney, L. Xue, S. Maurer-Stroh, D. E. Dwyer, B. Wang, D. W. Smith, A. Levy, R. Booy, R. Dixit, T. Merritt, A. Kelso, C. Dalton, D. Durrheim, and I. G. Bar

Hurt, A.

Wilson, N.

Deng, Y.

Leang, S.

Lee, R.

Givney, R.

Dwyer, D.

Smith, D.

et al.

Adelaide Research &amp; Scholarship

Characteristics of a widespread community cluster of H275Y oseltamivir-resistant a(H1N1)pdm09 influenza in Australia

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3379839

Characteristics of a Widespread Community Cluster of H275Y Oseltamivir-Resistant A(H1N1)pdm09 Influenza in Australia

Abstract

Similar works

Full text

Available Versions

University of Melbourne Institutional Repository

Digital Repository - Nanyang Technological University

DR-NTU (Digital Repository of NTU)

Crossref

University of Newcastle's Digital Repository

Adelaide Research & Scholarship

Characteristics of a Widespread Community Cluster of H275Y Oseltamivir-Resistant A(H1N1)pdm09 Influenza in Australia

Abstract

Similar works

Full text

Available Versions

University of Melbourne Institutional Repository

Digital Repository - Nanyang Technological University

DR-NTU (Digital Repository of NTU)

Crossref

University of Newcastle's Digital Repository

Adelaide Research &amp; Scholarship

Adelaide Research & Scholarship