The paper presents the trends in the evolution of occupational diseases in Romania in comparison to the EU and the US, as incidence of occupational diseases, their interrelationship with the exposure to occupational risk factors in the working environment, the dynamic changes over time of the traditional structure and of the hierarchy framework of employees’ check-up regarding the risk factors. The analysis covers the period 2010 - 2015 and was made in quantitative terms (statistical data) and qualitative terms (study concerning the causal factors of the employee’s work environment). The data are presented as absolute figures and the average annual incidence rates are presented per 100 000 people employed in this industry