NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents.

Desai, Tejal; El-Benna, J; Giacca, A; Ivovic, A; Joseph, JW; Koulajian, K; Liu, GC; Patterson, JN; Scholey, JW; Tang, C

NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents.

Authors: Tejal Desai
J El-Benna
A Giacca
A Ivovic
JW Joseph
K Koulajian
GC Liu
JN Patterson
JW Scholey
C Tang
Publication date: 21 February 2013
Publisher: eScholarship, University of California
Doi

Abstract

The activation of NADPH oxidase has been implicated in NEFA-induced beta cell dysfunction. However, the causal role of this activation in vivo remains unclear. Here, using rodents, we investigated whether pharmacological or genetic inhibition of NADPH oxi