Evangelia Papadavid

Konstantinos Douros

Konstantinos Priftis

Manthoula Valari

Maria Theodoridou

Maria-Alexandra Magiakou

Sophia Tsabouri

Vasiliki Gemou-Engesaeth

Clinical and Translational Allergy

PubMed

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P57 - Prognostic factors for asthma at school age in infants with atopic dermatitis

POSTER PRESENTATION Open Access
P57 - Prognostic factors for asthma at school age
in infants with atopic dermatitis
Sophia Tsabouri1*, Manthoula Valari1, Konstantinos Douros2, Vasiliki Gemou-Engesaeth3,
Maria-Alexandra Magiakou1, Evangelia Papadavid1, Maria Theodoridou1, Konstantinos Priftis4
From 3rd Pediatric Allergy and Asthma Meeting (PAAM)
Athens, Greece. 17-19 October 2013
Introduction
The prevalence of atopic dermatitis (AD), one of the most
common skin disorders seen in infants and children, is
increasing, similar to that of other atopic disorders, parti-
cularly asthma. Although children showing more severe
dermatitis have a higher risk of having more persistent
AD, the role of severity as prognostic determinants for
childhood asthma is not clearly determined.
Aim
To determine clinical and laboratory prognostic factors
in infants with AD for subsequent development of
asthma at school age.
Materials and methods
89 infants with AD aged 3 to 24 months were recruited
and followed up until the age of 8 years. The severity of
AD at the time of the initial visit was calculated by using
the SCORAD index, whereas the laboratory parameters
determined were: peripheral blood eosinophil count,
serum ECP, total IgE and specific IgE levels for a panel of
food and inhaled allergens. Every second year, parents
were interviewed about symptoms and diagnosis relevant
to asthma by using a standardized questionnaire. At the
end-visit, specific IgEs for the same panel of food and
inhaled allergens were measured and, pre- and post-
bronchodilator spirometry was performed.
Statistical analysis
For the purpose of univariate, descriptive analysis Fisher’s
exact tests were used and for the multivariate analysis of
data logistic regression models.
Results
The study population the age of 8 consisted of 72 children.
They had significantly increased the risk of asthma at
school age when sensitized to inhaled allergens in infancy
(p<0.001). Asthma development was significantly related
with ECP levels (p=0.019, OR: 1.10, CI: 1.01 – 1.20). None
of the other analyzed early life factors (ie, severity, sex,
presence of other atopic conditions, and family history of
atopy) showed any association with subsequent develop-
ment of asthma.
Conclusion
AD severity in infancy does not have any effect on the
future development of asthma. Prognostic determinants
were found to be allergic sensitisation to inhaled aller-
gens, as expected, and ECP levels, probably, as allergic
eosinophilic inflammation indicator.
Authors’ details
1Department of Pediatrics, Child Health Department, University of Ioannina,
Greece. 22nd Pediatric Clinic, University of Athens School of Medicine,
Children’s Hospital “P. and A. Kyriakou”, Athens, Greece. 31st Pediatric Clinic,
University of Athens School of Medicine, Children’s Hospital “Aghia Sofia”,
Athens, Greece. 4Department of Pediatric Pulmonology and Allergology, 3rd
Pediatric Clinic, University of Athens School of Medicine, ”Attikon” General
Hospital, Athens, Greece.
Published: 28 February 2014
doi:10.1186/2045-7022-4-S1-P112
Cite this article as: Tsabouri et al.: P57 - Prognostic factors for asthma at
school age in infants with atopic dermatitis. Clinical and Translational
Allergy 2014 4(Suppl 1):P112.
1Department of Pediatrics, Child Health Department, University of Ioannina,
Greece
Full list of author information is available at the end of the article
Tsabouri et al. Clinical and Translational Allergy 2014, 4(Suppl 1):P112
http://www.ctajournal.com/content/4/S1/P112
© 2014 Tsabouri et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.


http://dx.doi.org/10.1186/2045-7022-4-S1-P112

P57 - Prognostic factors for asthma at school age in infants with atopic dermatitis

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