The origins of the trypanosome genome strains Trypanosoma brucei brucei TREU 927, T. b. gambiense DAL 972, T. vivax Y486 and T. congolense IL3000

A MacLeod; A MacLeod; ALW De Gee; AP Cortez; AP Jackson; AP Jackson; B Dero; B Wellde; C Felu; CA Hoare; CJ Young; CMR Turner; CMR Turner; D Jefferies; D Mehlitz; D Richner; D Steverding; DG Godfrey; DK Masiga; E Goedbloed; E Goedbloed; E Zweygarth; ER Adams; F Mathieu-Daude; FJ van Deursen; FK Dar; G Hide; G Hide; GD Kanmogne; GD Kanmogne; H Hirumi; H Hirumi; H Hirumi; HKW Gathuo; I Morlais; ID Gumm; JD Barry; JK Gashumba; JK Stiles; JR Helm; JR Stevens; JR Stevens; JW Magona; L Peacock; LE Stephen; M Berriman; M Radwanska; MA Gray; N Biteau; N Downey; N Downey; O Balmer; P Butikofer; P Dukes; P Dukes; P Leeflang; PAO Majiwa; PAO Majiwa; PB Hamilton; PR Gardiner; PR Gardiner; R Brun; RA Masake; RAL Bayne; RP Beecroft; S D'Archivio; S Utz; SE Melville; SK Dickin; SK Moloo; SK Moloo; T Bromidge; T Sakurai; V Coustou; W Gibson; W Gibson; W Gibson; WC Gibson; WC Gibson; WC Gibson; Wendy Gibson; Y Eshita

The origins of the trypanosome genome strains Trypanosoma brucei brucei TREU 927, T. b. gambiense DAL 972, T. vivax Y486 and T. congolense IL3000

Abstract

The genomes of several tsetse-transmitted African trypanosomes (Trypanosoma brucei brucei, T. b. gambiense, T. vivax, T. congolense) have been sequenced and are available to search online. The trypanosome strains chosen for the genome sequencing projects were selected because they had been well characterised in the laboratory, but all were isolated several decades ago. The purpose of this short review is to provide some background information on the origins and biological characterisation of these strains as a source of reference for future users of the genome data. With high throughput sequencing of many more trypanosome genomes in prospect, it is important to understand the phylogenetic relationships of the genome strains