Influence of the endogenous opioid system on the liver has not been studied enough. To understand the damaging effects of stress on the liver and the hepatoprotective effects of opioids, a study was performed on stress-resistant and stress-susceptible animals
Найти похожи

Lyashev, Y. D.

Solin, A. V.

Tsygan, N. V.

English

Introduction: Influence of the endogenous opioid system on the liver has not been studied enough. To understand the damaging effects of stress on the liver and the hepatoprotective effects of opioids, a study was performed on stress-resistant and stress-susceptible animals.
        
          Materials and methods: The investigation was performed on 725 Wistar male-rats. Various types of stress were modeled: acute immobilization stress of various duration (3, 6 and 12 hours), chronic stress of limited mobility, swimming stress and traumatic stress (resection of 70% of the liver). Agonists of various types of opioid receptors in equimolar doses were injected to stressed animals at equimolar doses: DAGO – a mu-receptor agonist – at a dose of 6.3 mcg/kg, DSLET – a delta-receptor agonist – at a dose of 10 mcg/kg, and kappa receptor agonist dynorphin A (1-13) – at a dose of 20.1 mcg/kg.
        
          Results and discussion: The stress-limiting action of the studied opioids is characterized by the reduced hepatocyte dystrophy, microcirculation correction, a decreased concentration of lipid peroxidation metabolites, a suppressed cytolytic syndrome, a stimulated synthetic ability of the liver, and is more pronounced in stress- susceptible animals. The greatest stress-protective effect is shown after administering dynorphin A (1-13) in immobilization stress, and DAGO – in swimming stress. Dynorphin A (1-13) and DAGO manifested the most pronounced effect on the liver regeneration after resection. A preliminary stress simulation accelerates liver regeneration at the initial stage after resection.
        
          Conclusion: The hepatoprotective effect of opioids in stress depends on the typological peculiarities of animals. The results obtained offer a challenge of synthesizing new hepatoprotectors

Solin,Alexey

Lyashev,Yuri

Tsygan,Nikolay V.

ARPHA Preprints

Hepatoprotective effect of opioid peptides in stress

DSpace at Belgorod State University

Solin, Alexey V.

Lyashev, Yury D.

Tsygan, Nikolay V.

ZENODO

NEUROSURGERY ENTHUSIASTIC WOMEN SOCIETY

ARPHA OAI-PMH Endpoint

National Open Repository Aggregator (NORA)

Influence of the endogenous opioid system on the liver has not been studied enough. To understand the damaging effects of stress on the liver and the hepatoprotective effects of opioids, a study was performed on stress-resistant and stress-susceptible animals Найти похожи

http://dspace.bsu.edu.ru/bitstream/123456789/46294/1/Solin_Hepatoprotective.pdf

Hepatoprotective effect of opioid peptides in stress

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ARPHA Preprints

DSpace at Belgorod State University

ZENODO

NEUROSURGERY ENTHUSIASTIC WOMEN SOCIETY

ARPHA OAI-PMH Endpoint

National Open Repository Aggregator (NORA)

DSpace at Belgorod State University