Dhanaraj, C Justin

Janaki, G Boomadevi

Joseph, J

Joseyphus, R Selwin

Nagashri, K

English

PubMed

J Joseph

G Janaki

K Nagashri

R Joseyphus

C Dhanaraj

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POSTER PRESENTATION Open Access
Highly conjugated curcumin analog based
copper complexes towards tuberculosis:
synthesis, characterization and antimycobacterial
activity
J Joseph1*, G Boomadevi Janaki1, K Nagashri1, R Selwin Joseyphus2, C Justin Dhanaraj3
From First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012)
Chennai, India. 20-22 January 2012
Background
Current first-line drugs for the treatment of tuberculosis
consist of, i.e., isoniazid (INH), rifampin (RIF), ethambutol
(EMB), pyrazinamide (PZA), and streptomycin (STR).
Resistance to the first-line drugs causes treatment failure
and necessitates the use of the drugs with a prolonged per-
iod of therapy. New anti-tuberculous agents, especially the
ones with novel mechanisms of action are urgently
required. Curcumin is a naturally occurring yellow pig-
ment obtainable from the rhizomes of perennial herb Cur-
cuma longa Linn., has been shown to act upon several
important molecular targets in malignancy and inflamma-
tory cascades and hence is used to treat various disorders
including arthritis, Crohn’s disease, cardiovascular disor-
ders, psoriasis, cancers, and other pathologies. However,
poor water solubility and unsatisfactory pharmacokinetics
of curcumin necessitate search for new curcumin analogs.
In the present work, we described the synthesis and struc-
tural characterization of highly conjugated curcumin ana-
logs (acetoacetanilide) Knoevenagel condensates, their
Schiff bases, and corresponding copper conjugates.
Method
The anti- M. tuberculosis activities of the compounds
were determined using the MABA assay method.
Results
The minimum inhibitory concentration of copper com-
plexes has been performed against Mycobacterium
tuberculosis strain H37Rv. It is observed that the MIC
values of copper complexes (2-6 µg/ml) are slightly
greater than the drug, ethambutol (1 µg/ml).
Conclusion
Copper complexes have higher anti-mycobacterial activ-
ity than ligands due to the presence of highly conjugated
curcumin analog system containing two azomethine
groups and redox properties of metal. Based on our stu-
dies, we conclude that copper complex may be a pro-
mising candidate against tuberculosis.
Author details
1Department of Chemistry, Noorul Islam Centre for Higher Education,
Kumaracoil-629 180, Tamil Nadu, India. 2Department of Chemistry, St John’s
College, Anchal, Kerala, India. 3Department of Chemistry, Anna University
Tirunelveli, Tirunelveli, Tamil Nadu, India.
Published: 4 May 2012
doi:10.1186/1471-2334-12-S1-P51
Cite this article as: Joseph et al.: Highly conjugated curcumin analog
based copper complexes towards tuberculosis: synthesis,
characterization and antimycobacterial activity. BMC Infectious Diseases
2012 12(Suppl 1):P51.
* Correspondence: chem_joseph@yahoo.co.in
1Department of Chemistry, Noorul Islam Centre for Higher Education,
Kumaracoil-629 180, Tamil Nadu, India
Full list of author information is available at the end of the article
Joseph et al. BMC Infectious Diseases 2012, 12(Suppl 1):P51
http://www.biomedcentral.com/1471-2334/12/S1/P51
© 2012 Joseph et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.


Highly conjugated curcumin analog based copper complexes towards tuberculosis: synthesis, characterization and antimycobacterial activity

Joseph J

Janaki G

Nagashri K

Joseyphus R

Dhanaraj C

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Highly conjugated curcumin analog based copper complexes towards tuberculosis: synthesis, characterization and antimycobacterial activity

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