This lecture by Dr. Vincent Rotello will present his lab\u27s recent research in the areas of therapeutics and diagnostics using gold nanoparticles

Rotello, Vincent

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University of Massachusetts Medical School eScholarship@UMMS UMass Center for Clinical and Translational Science Seminar Series 2013 UMCCTS Seminar Series Jan 24th, 12:00 PM Nanoparticles in Biomedicine: Delivery and Sensing Vincent Rotello University of Massachusetts - Amherst Let us know how access to this document benefits you. Follow this and additional works at: https://escholarship.umassmed.edu/umccts_seminars  Part of the Nanomedicine Commons, Nanoscience and Nanotechnology Commons, Organic Chemistry Commons, Therapeutics Commons, and the Translational Medical Research Commons Rotello V. (2013). Nanoparticles in Biomedicine: Delivery and Sensing. UMass Center for Clinical and Translational Science Seminar Series. Retrieved from https://escholarship.umassmed.edu/umccts_seminars/2013/seminars/1 Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 License. This material is brought to you by eScholarship@UMMS. It has been accepted for inclusion in UMass Center for Clinical and Translational Science Seminar Series by an authorized administrator of eScholarship@UMMS. For more information, please contact Lisa.Palmer@umassmed.edu. Nanoparticles in Biomedicine: Delivery and SensingVincent Rotello University of MassachusettsI) Nanoparticle therapeuticsa)  Supramolecular triggeringb)  ImmunomodulationII) Deliverya)  Nanoparticle capsulesb)  Protein deliveryII) Sensinga)  Proteinsb)  Cell surfacesc)  TissuesDuncan, B.; Kim, C.; Rotello, V. M. J. Control. Release, 2010, 148, 122-127. 2 nm core diameter Au particles -stable in biofluids (inc serum)-redispersibleKim, C.-K.; Agasti, S. S.; Zhu, Z.J.; Isaacs, L.;  Rotello, V.M. Nature Chem., 2010, 2, 962-966. Moyano, D. F.; Goldsmith, M.; Solfiell, D. J.; Landesman-Milo, D.; Miranda, O. R.;  Peer D.*; Rotello, V. M.* J. Am. Chem. Soc., in press Patra, D.; Sanyal, A.; Rotello, V. M.  Chem.-Asian J., 2010, 5, 2442-2453.  Yang, X.-C.; Samanta, B.; Agasti, S. S,; Jeong, Y.; Zhu, Z.-J.;  Rana, S.; Miranda, O.R.; Rotello, V. M.” Angew. Chem., 2011 50, 477-481 .  can we use this strategy for cell surface sensing? the key is tuning the interfaceAu nanoparticles bound to analytes don’t look much different than unbound De. M.; Rana, S.; Akpinar, H.; Miranda, O.R.; Arvizo, R. R.; Bunz, U. H. F.; Rotello, V. M. Nature Chem. 2009, 1, 461-465.  Bajaj, A.; Miranda, O. R.; Kim, I.-K.; Phillips, R. L.; Jerry, D. J.;  Bunz, U. H. F.; Rotello, V. M. Proc. Nat. Acad. Sci., 2009, 106, 10912-10916. The “out of time” summary:Gold nanoparticles provide:Potential therapeutics-triggered cytotoxicity-tunable immunomodulationBuilding blocks for nanocapsules-for drug and protein delivery-direct to the cytosol!Effective “chemical nose” sensors for:-cancer cells (healthy, cancerous, metastatic)-metastases (induced—the real thing!)Alumni: grad students Bing NieEric BreinlingerMichael GreavesAngelika NiemzRobert DeansAlex CuelloTrent GalowFaysal IlhanEunhee JeoungMark GrayAndy BoalKanad DasKate GoodmanJoe SimardRay ThibaultJoe CarrollOktay UzunNick FischerBen FrankampRui Hong Basar GiderAyush VermaHiroshi NakadeHao XuGang HanSud SrivastavaBrian JordanRochelle ArvizoMrinmoy DeBappa SamantaPartha GhoshOscar MirandaApiwat ChampoosorMyoung-Hwan ParkJiang XuChaekyu KimAlumni: postdocs Gilles ClavierAllan GoodmanAlam SyedUlf DrechslerC-C YouAmitav SanyalAcknowledgments:Tyler NorstenRoy ShenharBelma Erdogan“Pops” ArumugamAmitav SanyalYuval OfirCurrent: postdocSung-Tae KimVikas NandwanaChang Soo KimSerdar BurmaogluYoni EnglenCurrent: gradsYu XiChandra SubramaniSubinoy RanaDave SolfielBrian CreranXiaoning LiYoungdo JeongYi-Cheun YehBo YanKrishendu SahaDaniel MoyanoBrad DuncanYing JiangRobul MoutGulen YesilbagRyan LandisNgoc LeMoumita RayYuqing XingCollaboratorsCraig MartinMike KnappRichard VachetPaul Lahti“Thai” ThayumanavanTodd Emrick (PSE) Tom Russell (PSE)Mark Tuominen (Phys) Joe Jerry (Vet.An.Sci)Sallie Smith (Vet.Ani.Sci)Neil Forbes (Chem. E)Maria Santore (PSE)Jim Watkins (PSE)Uwe Bunz (H-Burg)Jean Chmielewski(Purdue)Bogdan Dragnea (IU)Graeme Cooke (Glasgow)M.B. Holl (Michigan)Lyle Isaacs (Maryland)Dan Peer (Tel Aviv)FundingNIH,NSF, ONR, DOENSF CHM-NSECNSF MRSEC, ArmyKeck FoundationBAE, Teijin, Firmenich

Nanoparticles in Biomedicine: Delivery and Sensing

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Nanoparticles in Biomedicine: Delivery and Sensing

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